Understanding early pregnancy loss through genetic analysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the genetic and immunological factors contributing to early pregnancy loss, which affects approximately one in four women. It focuses on analyzing products of conception obtained through ultrasound-guided manual vacuum aspiration (MVA) to identify chromosomal abnormalities and other genetic factors that may not be detectable by conventional karyotyping. The study utilizes next-generation sequencing (NGS) to enhance the detection of genomic variants, including copy-number variants and low-level chromosomal mosaicisms. By improving the understanding of the genetic underpinnings of miscarriage, the study seeks to provide insights into potential causes and future interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Women 18 years old or above
2. Women with miscarriage or TOP who are suitable candidates for MVA

   * first trimester miscarriage or TOP
   * No fetal heart beat or TOP in those with CRL 25mm
   * incomplete miscarriage or TOP with POG \<5cm
   * hemodynamically stable,
   * tolerates well with speculum examination

Exclusion Criteria:

1. Women who are not feasible for the MVA procedure

   * cervical stenosis
   * fibroid uterus \>12 weeks in size
   * known uterine malformation
   * bleeding disorder
   * clinically sepsis
   * inability to tolerate pelvic examination
2. History of psychological/ psychiatric problem
3. Patient refusal

Where it's running

• Prince of Wales Hospital
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Pui Wah Jacqueline Chung — Prince of Wales Hospital, Shatin, Hong Kong
• Study coordinator: Pui Wah Jacqueline Chung
• Email: jacquelinechung@cuhk.edu.hk
• Phone: 35051537

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.