Ultrasound-guided microwave ablation for benign thyroid nodules
Official title: Ultrasound-guided Microwave Ablation of Benign Thyroid Nodules
Run by Chinese University of Hong Kong · NCT07906821 · Data updated 2026-11-12
This study tests whether using ultrasound-guided microwave ablation to shrink benign thyroid nodules under local anesthesia is safe and effective, compared with traditional surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Shatin) |
| Status | Recruiting |
| Started | August 31, 2023 |
| Main results expected | May 31, 2029 |
| Study ends | May 31, 2029 |
| Registry record updated | November 2, 2026 |
| Trial ID | NCT07906821 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with symptomatic benign thyroid nodules (≥2 cm) confirmed by FNAC, suitable for a minimally invasive, ultrasound-guided procedure.
✕Probably not a fit
Patients with malignant nodules, asymptomatic nodules, or contraindications to ablation may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, single-arm study enrolls adults with symptomatic benign thyroid nodules (nodule size ≥2 cm) confirmed benign by FNAC. Participants undergo ultrasound-guided microwave ablation, with real-time ultrasound monitoring to limit ablation to the target area while avoiding critical structures. Follow-up visits occur at 2 weeks, 3 months, 6 months, 12 months, 2 years, and 3 years to assess symptoms, cosmetic satisfaction, and other outcomes. Outcomes focus on nodule shrinkage, safety, and patient-reported experiences during and after treatment.
Why it matters
Potential benefit: If successful, patients may experience reduced nodule size and symptom relief with a less invasive option under local anesthesia.
How similar studies have gone: Prior studies suggest microwave ablation can reduce thyroid nodule size, but this specific strategy under local anesthesia with real-time ultrasound guidance is being further evaluated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Thyroid nodules or dominant nodule of multinodular goitre * Symptomatic thyroid nodule not less than 2cm * Benign thyroid nodule confirmed by Fine needle aspiration for cytology (FNAC) Exclusion Criteria: * Asymptomatic thyroid nodule * Malignant thyroid nodule * High risk USG features or cytological features * Previous anterior neck surgery * Previous radiotherapy at the head and neck region * Presence of another malignancy, lateral neck, or distant metastasis * Cervical spine disease precluding extension of the neck * Patients under 18 years old * Vulnerable population (e.g. Cognitive impairment, pregnancy) * Obesity with BMI \> 35kg/m2 * Severe concomitant illness that drastically shortens life expectancy or increases risk of therapeutic intervention * Non-correctable coagulopathy
Where it's running
-
The Chines University of Hong Kong
Shatin, Hong Kong Recruiting
Study contacts
- Principal investigator: Samuel Chung Chie Cheng — Chinese University of Hong Kong
- Study coordinator: Samuel Chung Chie Cheng
- Email: ccc353@ha.org.hk
- Phone: 852 + 95173435
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.