Understanding diabetes treatment in pregnant women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of metformin in treating gestational diabetes mellitus (GDM) by comparing treatment outcomes between patients with different metabolic profiles. It focuses on women diagnosed with GDM, specifically those experiencing insulin resistance versus those with low insulin secretion. The study will track various parameters, including glucose levels, insulin sensitivity, and weight gain, to better tailor treatment approaches for pregnant women with GDM. A total of 103 participants will be monitored during late pregnancy to assess the need for additional insulin treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* having a confirmed single, viable pregnancy past 20 weeks gestation.
* assigned to pharmacological (ie metformin) treatment for GDM.

Exclusion Criteria:

* pre-existing diabetes, hypertension (SBP \>160 mmHg \& DBP \>110 mmHg)
* using medication related to study outcomes prior to GDM diagnosis (insulin, metformin, glyburide, systemic steroids, mood stabilizers, ADHD medication)
* smoking or using recreational drugs that may affect pregnancy outcomes

Where it's running

• Zuyderland Medisch Centrum
  Heerlen, Netherlands Recruiting

Study contacts

• Principal investigator: Jasper Most, PhD — Zuyderland Medisch Centrum
• Study coordinator: Jasper Most, PhD
• Email: j.most@zuyderland.nl
• Phone: 0031625159747

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Islet function in gestational diabetes: see if pancreas changes during and after pregnancy

  This study tests whether the human pancreas changes its function during and after pregnancy in people with gestational diabetes or not, using Exendin 9-39 in a small Phase 1 trial.

  Recruiting Phase 1 Mayo Clinic · Rochester, Minnesota · NCT07806695

• Prenatal Exercise to See How Cardio or Strength Training Affects Blood Sugar

  This study tests whether different types and amounts of exercise during pregnancy can improve blood sugar control in women with gestational diabetes.

  Recruiting University of Central Arkansas · Conway, Arkansas · NCT07802262

• Early Glucose Patterns in Pregnant Women at Risk for GDM

  This study tests whether continuous glucose monitoring in early pregnancy can detect dysglycemia before GDM is diagnosed, in women with and without known risk factors.

  Recruiting DCB Research AG · Bern, Canton of Bern · NCT07783178

• Probiotic-augmented therapy for gestational diabetes

  This trial tests whether adding multistrain probiotics to metformin, insulin, or their combination can improve blood sugar control and inflammation in pregnant women with gestational diabetes.

  Recruiting Riphah International University · Rawalpindi, Punjab Province · NCT07645001

• Maternal insulin and fat metabolism in pregnancies at risk for preeclampsia and gestational diabetes

  This project will try to see if insulin resistance and how the body burns fats early in pregnancy predict later preeclampsia or gestational diabetes in people at higher risk.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07565727

• How sleep, lifestyle, and metabolism relate to pregnancy outcomes in gestational diabetes

  This project will see if sleep quality, anxiety, eating and activity habits, and metabolic markers relate to blood sugar control and birth outcomes in pregnant people with gestational diabetes.

  Recruiting University of Split, School of Medicine · Split · NCT07314944

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.