Understanding blood flow issues after brain bleeding
Ischaemic Lesions in Acute Intracerebral Haemorrhage: Pathophysiological Investigation Using Novel Multimodal Cerebral and Systemic Haemodynamic Assessments
This study looks at how blood flow problems after a brain bleed affect recovery and aims to find better ways to manage blood pressure for patients who have had an intracerebral hemorrhage.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 120 Years |
| Sex | All |
| Sponsor | University of Leicester Academic / other |
| Locations | 1 site (Leicester) |
| Trial ID | NCT06410274 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the causes of inadequate brain blood flow following intracerebral hemorrhage (ICH). Participants will undergo assessments using transcranial Doppler (TCD) within 48 hours of hospital admission and again at 4-7 days post-ICH onset, along with an MRI scan after 7 days. The study seeks to clarify the relationship between blood pressure management and brain perfusion, particularly how these factors may lead to ischemic lesions after ICH. By analyzing these dynamics, the research hopes to provide insights into better management strategies for patients with ICH.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have been clinically diagnosed with a hemorrhagic stroke within 48 hours of onset.
Not a fit: Patients who are under 18 years old, have contraindications for MRI, or are clinically unstable may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols for patients suffering from intracerebral hemorrhage, potentially reducing the risk of further brain damage.
How similar studies have performed: While the approach of assessing blood flow in ICH patients is established, this specific investigation into the relationship between blood pressure management and ischemic lesions is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of a haemorrhagic stroke on CT imaging within 48 hours of onset (for patients waking with a stroke, time of onset will be taken to be the time when the patient was last asymptomatic). * Male or female, aged 18 years or above. Exclusion Criteria: * MRI imaging is contraindicated or unlikely to tolerate scanning process due to clinical instability (GCS \<8, unable to lie supine). * Patients requiring anaesthesia. * Male or Female, aged under 18 years. * Clinical diagnosis of stroke greater than 48 hours from onset
Where this trial is running
Leicester
- University Hospitals of Leicester NHS Trust — Leicester, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Jatinder Minhas, SFHEA
- Email: jm591@leicester.ac.uk
- Phone: +44 116 252 3299
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.