Understanding blood flow issues after brain bleeding
Official title: Ischaemic Lesions in Acute Intracerebral Haemorrhage: Pathophysiological Investigation Using Novel Multimodal Cerebral and Systemic Haemodynamic Assessments
Run by University of Leicester · NCT06410274 · Data updated 2026-11-12
This study looks at how blood flow problems after a brain bleed affect recovery and aims to find better ways to manage blood pressure for patients who have had an intracerebral hemorrhage.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 120 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | University of Leicester Academic / other |
| Locations | 1 site (Leicester) |
| Status | Recruiting |
| Started | June 1, 2024 |
| Main results expected | January 31, 2029 |
| Study ends | January 31, 2029 |
| Registry record updated | September 19, 2024 |
| Trial ID | NCT06410274 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have been clinically diagnosed with a hemorrhagic stroke within 48 hours of onset.
✕Probably not a fit
Patients who are under 18 years old, have contraindications for MRI, or are clinically unstable may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the causes of inadequate brain blood flow following intracerebral hemorrhage (ICH). Participants will undergo assessments using transcranial Doppler (TCD) within 48 hours of hospital admission and again at 4-7 days post-ICH onset, along with an MRI scan after 7 days. The study seeks to clarify the relationship between blood pressure management and brain perfusion, particularly how these factors may lead to ischemic lesions after ICH. By analyzing these dynamics, the research hopes to provide insights into better management strategies for patients with ICH.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols for patients suffering from intracerebral hemorrhage, potentially reducing the risk of further brain damage.
How similar studies have gone: While the approach of assessing blood flow in ICH patients is established, this specific investigation into the relationship between blood pressure management and ischemic lesions is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of a haemorrhagic stroke on CT imaging within 48 hours of onset (for patients waking with a stroke, time of onset will be taken to be the time when the patient was last asymptomatic). * Male or female, aged 18 years or above. Exclusion Criteria: * MRI imaging is contraindicated or unlikely to tolerate scanning process due to clinical instability (GCS \<8, unable to lie supine). * Patients requiring anaesthesia. * Male or Female, aged under 18 years. * Clinical diagnosis of stroke greater than 48 hours from onset
Where it's running
-
University Hospitals of Leicester NHS Trust
Leicester, United Kingdom Recruiting
Study contacts
- Study coordinator: Jatinder Minhas, SFHEA
- Email: jm591@leicester.ac.uk
- Phone: +44 116 252 3299
Similar studies
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Stereotactic tenecteplase clot liquefaction for supratentorial intracerebral hemorrhage
This trial will see if stereotactic minimally invasive clot drainage plus a single low dose of tenecteplase helps adults with moderate-to-large supratentorial intracerebral hemorrhage recover better than standard medical care.
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When and how people recover after an intracerebral hemorrhage
This registry will collect detailed, long-term data on adults who have surgery for intracerebral hemorrhage to see if the timing and type of surgical treatment affect recovery and quality of life.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.