When and how people recover after an intracerebral hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The TORCH registry is a prospective, observational cohort enrolling adults with acute, spontaneous supratentorial intracerebral hemorrhage who receive surgical treatment at Xuanwu Hospital. It will collect standardized, longitudinal data on clinical presentation, imaging (CT/CTA), surgical modality (including endoscopic evacuation, minimally invasive surgery with urokinase, and craniotomy), timing of intervention, and functional and quality-of-life outcomes. Eligibility includes age 18–80, baseline mRS ≤1, and defined severity thresholds (NIHSS ≥6 or GCS 5–15); patients with secondary causes of hemorrhage or irreversible coagulopathy are excluded. By comparing outcomes across interventions and timing, the registry aims to produce granular, real-world evidence to guide surgical decision-making.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subject Age is ≥18 to ≤80 years
* Subject with a Head CT/CTA that demonstrates an acute, spontaneous, primary, supratentorial ICH, assessed via standard of care techniques
* Subject recieving a surgery intervention
* Subject has a NIHSS score ≥ 6 or GCS score 5≤GCS≤15
* Subject has a baseline Modified Rankin Scale (mRS) Score ≤ 1

Exclusion Criteria:

* Secondary intracerebral hemorrhage (with leading cause, e.g., Moyamoya disease, arteriovenous malformation, intracranial aneurysm, tumor, brain trauma)
* Pre-stroke life expectancy \< 1 year for severe comorbidities (e.g., Progressive malignant tumor, severe chronic heart failure \[NYHA: III-IV\], severe chronic obstructive pulmonary disease \[III-IV\], chronic kidney disease requiring hemodialysis)
* Patients with platelet count \< 100,000, INR \> 1.4, or an elevated PT or APTT (reversal of coumadin is permitted but the patient must not require coumadin during the acute hospitalization). Irreversible coagulopathy either due to medical condition or prior to randomization
* Pregnant (positive pregnancy test) or lactating females (likelihood of altered coagulation function associated with the high estrogen/progesterone state)
* Irreversibly impaired brainstem function (bilateral fixed, dilated pupils and extensor motor posturing), GCS less than or equal to 4

Where it's running

• The Department of Neurosurgery, China International Neuroscience Institute, Xuanwu Hospital, Capital Medical University,
  Beijing, China Recruiting

Study contacts

• Study coordinator: Tao Hong, MD
• Email: hongtao.edu@gmail.com
• Phone: +86-13810000653

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.