Reducing the risk of heart and brain events after intracerebral hemorrhage with aspirin

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

BEAT ICH is a large, pragmatic, randomized, placebo-controlled trial designed to see if daily aspirin (75 mg) reduces major adverse cardiovascular and cerebrovascular events in adults who have survived an intracerebral hemorrhage. Participants are randomly assigned to aspirin or placebo for the duration of follow-up, with the length of treatment and follow-up varying by when they enroll. The study plans to enroll about 5,676 participants across 50 stroke centers in India and follow them for up to three years. The primary outcome is the net reduction in MACE over the long term. The trial builds on prior evidence suggesting potential benefits of antiplatelet therapy in this population, while addressing the uncertainty about safety and effectiveness in ICH survivors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* First-ever Intracerebral Haemorrhage
* Presenting ≥24 hrs up to 3 months of stroke symptoms confirmed by brain imaging
* CT /MRI confirming Intracerebral Haemorrhage
* Alive ≥24 hours after non-traumatic ICH

Exclusion Criteria:

* ICH is known to be due to trauma, a structural cause (e.g., aneurysm, arteriovenous malformation, cerebral cavernous malformation, venous thrombosis, or tumour), or haemorrhagic transformation of cerebral infarction
* Glasgow coma score ≤5
* Taking any antiplatelet or anticoagulant therapy 15 days prior to randomization.
* Women pregnant, breastfeeding, childbearing potential, and not using contraceptives
* Enrolled in any other clinical trial
* Sick or compromised patients with life expectancy of less than a year
* Geographical or other factors that prohibit long-term follow-up

Where it's running

• Government General Hospital
  Guntur, Andhra Pradesh, India Recruiting
• Lalitha Super Specialty Hospital
  Guntur, Andhra Pradesh, India Recruiting
• Dr Ramesh Cardiac and Multispecialty Hospital
  Guntur, Andhra Pradesh, India Recruiting
• Government General Hospital
  Kākināda, Andhra Pradesh, India Recruiting
• Narayana Medical College and Hospital
  Nellore, Andhra Pradesh, India Recruiting
• Apollo Excelcare Hospitals
  Guwahati, Assam, India Recruiting

Study contacts

• Principal investigator: Jeyaraj D Pandian, MD, DM — Christian Medical College and Hospital, Ludhiana, Punjab, India
• Study coordinator: Jeyaraj D Pandian, MD, DM
• Email: jeyarajpandian@hotmail.com
• Phone: +919915784750

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.