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Understanding Biliary Atresia in Children

Biliary Atresia Study in Infants and Children (BASIC)

Observational Arbor Research Collaborative for Health · NCT00345553

This study is trying to learn more about biliary atresia in children by collecting health information and samples to see what causes the disease and how it affects their lives.

Quick facts

Study typeObservational
Enrollment1265 (estimated)
Ages6 Months to 20 Years
SexAll
SponsorArbor Research Collaborative for Health Academic / other
Locations16 sites (Los Angeles, California and 15 other locations)
Trial IDNCT00345553 on ClinicalTrials.gov

What this trial studies

This observational study aims to gather clinical information, genetic material, and body fluid samples from children diagnosed with biliary atresia (BA) to explore the causes and progression of the disease. It focuses on identifying genetic defects and autoimmune factors that may contribute to BA and its complications. The study also seeks to characterize the natural history of older children with BA, examining how sentinel events like variceal bleeding and growth failure may predict outcomes such as liver transplantation or mortality. By comparing these children to healthy controls, the study aims to enhance understanding of the disease's impact on quality of life.

Who should consider this trial

Good fit: Ideal candidates for this study are children aged 6 months to 20 years with a confirmed diagnosis of biliary atresia.

Not a fit: Patients currently participating in the ChiLDReN study PROBE or those unable to confirm their original diagnostic evaluation of biliary atresia may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and management of biliary atresia, potentially enhancing patient outcomes.

How similar studies have performed: While there have been studies on biliary atresia, this approach focusing on older children and genetic factors is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Participants need to have a confirmed diagnosis of BA determined by chart review including review of pertinent diagnostic biopsy reports, radiologic reports and surgical reports (if surgery was performed).
2. Participants need to be \>6 months of age up to and equal to the age of 20 (participants enrolled at 20 years of age will have one visit).
3. Participants with their native liver.
4. Parent, guardian or participant (if 18 years of age or older) is willing to provide informed consent and, when appropriate, the participant is willing to assent.

Exclusion Criteria:

1. Currently participating in the ChiLDReN study PROBE.
2. Inability to confirm original diagnostic evaluation of biliary atresia.
3. Inability or unwillingness of family or participant to participate in all scheduled visits.
4. History of liver transplantation.

Where this trial is running

Los Angeles, California and 15 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Biliary AtresiaCholestasis
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.