High-MCT nutritional support for infants with biliary atresia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective interventional comparison will give intensified enteral feeding with a high MCT formula during the perioperative period to infants with biliary atresia and compare outcomes to those receiving traditional oral feeding. Eligible infants are under three months old and scheduled to undergo Kasai portoenterostomy, with parental consent required for participation. Study staff will monitor growth measurements, biochemical nutritional markers, and clinical recovery after surgery to determine effects on nutritional status and short-term prognosis. Infants with very low birth weight, severe comorbidities, major digestive tract malformations, recent participation in other trials, or other contraindications will be excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Infants under 3 months old;
* Children clinically diagnosed with biliary atresia and in need of Kasai surgery;
* The patient themselves, legal representative or guardian have signed the informed consent form and are willing to actively cooperate with treatment and follow-up.

Exclusion Criteria:

* Low birth weight infants or very low birth weight infants;
* Complicated with life-threatening diseases of various organ systems;
* Complicated with other severe digestive tract malformations or other diseases that may interfere with the treatment of the patient or the patient's compliance;
* Patients who have participated in other clinical trials within the last month;
* Any other conditions that the researcher deems unsuitable for participation in this trial.

Where it's running

• Tongji Hospital
  Wuhan, Hubei, China Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Umbilical cord stem cells added during Kasai to help biliary atresia

  This early-stage trial tests whether injecting umbilical cord mesenchymal stem cells during Kasai portoenterostomy is safe and helpful for infants with biliary atresia.

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• Indocyanine green for diagnosing biliary atresia

  This test tries to see if a harmless fluorescent dye (indocyanine green) can show whether infants under 3 months with cholestasis have blocked bile ducts (biliary atresia).

  Recruiting Phase 1/2 Boston Children's Hospital · Boston, Massachusetts · NCT07513038

• Using near-infrared ICG dye to check bile flow in newborns with cholestasis

  We will give eligible newborns a single IV dose of indocyanine green (ICG) to see if the dye appears in their diapers, which would indicate bile is flowing and the bile ducts are open.

  Recruiting Early Phase 1 University of Alabama at Birmingham · Birmingham, Alabama · NCT07250854

• Using oral antibiotics to prevent cholangitis after liver surgery in infants

  This study is testing if giving oral antibiotics to infants after liver surgery can help prevent cholangitis, compared to those who don’t receive the antibiotics.

  Recruiting Children's Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT05925309

• Investigating serum FGF19 levels for predicting outcomes in biliary atresia

  This study is testing if measuring a specific protein in the blood can help doctors predict how well children with biliary atresia will do after surgery.

  Recruiting Children's Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT05848310

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.