UIC multi-ethnic dilated cardiomyopathy registry
University of Illinois Chicago (UIC) Multi-Ethnic Dilated Cardiomyopathy (DCM) Registry
This project will collect genetic and social data from adults with dilated cardiomyopathy, especially African American and Hispanic/Latino patients, to see if certain genes and social factors explain worse outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Illinois at Chicago Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Trial ID | NCT07145138 on ClinicalTrials.gov |
What this trial studies
This observational registry enrolls adults with dilated cardiomyopathy seen at the University of Illinois Hospital to collect clinical data, family history, genetic samples, and measures of social and financial stressors. Participants provide written consent and contribute blood or saliva for genetic analysis, complete surveys on social determinants of health, and allow review of their medical records. Investigators will compare the frequency of known and novel genetic variants and the impact of social/medical burdens across racial and ethnic groups. The aim is to determine whether genetic differences and nonmedical stressors help explain higher DCM severity and worse outcomes in minority populations.
Who should consider this trial
Good fit: Adults age 18 or older with dilated cardiomyopathy or heart failure who are seen at University of Illinois Hospital and can give written informed consent, especially African American or Hispanic/Latino patients.
Not a fit: People who are pregnant, incarcerated, minors, unable to consent, or who do not receive care at the study site are unlikely to join or benefit directly from this registry.
Why it matters
Potential benefit: If successful, the findings could improve genetic diagnosis and lead to targeted care strategies that reduce the disproportionate burden of DCM in minority patients.
How similar studies have performed: Genetic studies in predominantly White cohorts have identified several DCM-causing genes, but similar multi-ethnic investigations are limited, so this approach builds on partial prior success but remains under-tested in minority groups.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Must be at least 18 years of age and be admitted to or seen at a UIH site. * Subjects must be willing and able to give written, informed consent Exclusion Criteria: * Adults who are unable to provide consent * Women who are pregnant at the baseline visit, * Prisoners * Individuals who are not yet adults (infants, children, teenagers).
Where this trial is running
Chicago, Illinois
- University of Illinois Hospital & Health Sciences — Chicago, Illinois, United States (Recruiting)
Study contacts
- Study coordinator: David Tofovic, M.D.
- Email: dtofov2@uic.edu
- Phone: 312-355-7111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.