Trying DAILIES TOTAL1 Multifocal Lenses in satisfied INFUSE wearers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study examines comfort and vision when refitting experienced INFUSE One-Day Multifocal wearers with DAILIES TOTAL1 Multifocal lenses. Eligible participants are 40 years and older who currently wear INFUSE multifocal lenses and meet daily-wear and dry-eye criteria. The study focuses on lens materials that support a healthy tear film and stable optical performance over extended wear. Participants will wear the DAILIES TOTAL1 Multifocal lenses for at least 8 hours per day, five days a week, and complete study questionnaires to assess comfort and vision outcomes. The approach aims to determine if a high-oxygen water-gradient or osmoprotective lens design can sustain physiological comfort without compromising visual clarity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Age ≥40 years at enrollment Current satisfied wearer of Bausch + Lomb INFUSE One-Day Multifocal (kalifilcon A) in both eyes; Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) score \<12 at baseline Minimum contact lens wear of ≥8 hours/day, ≥5 days/week, for ≥30 days prior to Visit 1 Best-corrected distance visual acuity ≥20/25 (0.18 LogMAR) or better in each eye Manifest refraction within study lens parameters (Sphere: +6.00 D to -10.00 D; Add: Low, Medium, High) Willing to wear DAILIES TOTAL1 Multifocal lenses for ≥8 hours/day, ≥5 days/week and complete all study questionnaires Able to provide written informed consent and comply with investigator instructions

Exclusion Criteria:

Active ocular infection, inflammation, or clinically significant ocular surface disease (e.g., severe dry eye, pterygium, keratoconus) Uncontrolled systemic disease or use of systemic medications known to significantly affect the tear film, unless on a stable dose for ≥90 days History of refractive surgery (LASIK, PRK, RK) or intraocular surgery (cataract or IOL implantation) Clinically significant ectropion, entropion, or trichiasis Baseline corneal fluorescein staining score \>2 in any single zone (NEI/Industry scale) Current monovision or modified monovision contact lens wear Pregnant or lactating participants Participation in another clinical trial within 30 days prior to enrollment

Where it's running

• Gordon Schanzlin New Vision Institute
  La Jolla, California, United States Recruiting

Study contacts

• Study coordinator: David Geffen, OD, FAAO
• Email: dgeffen@gwsvision.com
• Phone: 8584556800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.