TROP2-targeting NIR-II probe for real-time OSCC imaging during surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will apply a TTP-ICG imaging solution to freshly excised oral tissue during planned surgery for OSCC or benign oral tumors. The tissue is incubated with different concentrations of the probe, rinsed, and then imaged with an NIR-II system to measure fluorescence. Pathology and immunohistochemistry will follow to compare imaging results with gold-standard diagnoses. The goal is to see if the fluorescent signal correlates with cancer presence and can improve diagnostic accuracy intraoperatively.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age range: 18-75 years old;

  * Patients with oral cancer or benign oral tumors who plan to undergo surgical intervention;

    * Preoperative coagulation function test was normal; ④ No serious underlying diseases; ⑤ WHO Physical Status Score 0-2 points;

      * Sign the informed consent form;

Exclusion Criteria:

* Suffering from other invasive malignant tumors;

  * Surgery cannot be performed for other serious illnesses; ③ Suffering from mental disorders and unable to sign informed consent forms on their own;

    * The subject requests to withdraw from the clinical trial; ⑤ The researchers believe that it is not appropriate for them to continue participating in this clinical trial.

Where it's running

• Yunnan Cancer Hospital
  Kunming, Yunnan, China Recruiting

Study contacts

• Study coordinator: Yixin Chen, postgraduate
• Email: 844907195@qq.com
• Phone: 86+ 18305902616

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• AI analysis of ECGs to detect structural heart disease

  This project will test whether AI can read traditional and wearable ECGs to find undiagnosed valve disease, pulmonary hypertension, and heart failure in adults.

  Recruiting at 6 sites Imperial College London · Bristol and 5 other locations · NCT07057466

• Shoulder-sparing neck surgery: comparing levels I-III vs I-IV in oral cancer with no neck nodes

  This trial tests whether removing lymph nodes only from levels I-III is as effective as extending to level IV for adults with oral squamous cell carcinoma that has no neck metastasis.

  Recruiting Kolhapur Cancer Centre - Cancer Centers of America · Kolhāpur, Maharashtra · NCT07726199

• Heart failure with preserved ejection fraction in people with COPD: clinical course and prognosis

  This project will see how often HFpEF appears in people aged 50–70 hospitalized with COPD and whether having HFpEF changes their symptoms, exercise capacity, and prognosis.

  Recruiting at 2 sites National Medical Research Center for Therapy and Preventive Medicine · Kazan' and 1 other locations · NCT07375433

• Sintilimab with chemotherapy before and after surgery for locally advanced oral squamous cell carcinoma

  This trial will test whether adding sintilimab to chemotherapy before and after surgery helps people with locally advanced oral squamous cell carcinoma have fewer recurrences and better survival.

  Recruiting Phase 3 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07371611

• Hydrogen water oral care after free flap reconstruction for oral cancer

  A randomized trial tests whether hydrogen water oral care helps reduce inflammation and pain and improve oral bacteria after surgery for oral cancer.

  Recruiting Kaohsiung Medical University Chung-Ho Memorial Hospital · Kaohsiung City · NCT07306546

• Neoadjuvant immunochemotherapy to shrink advanced oral and oropharyngeal cancers before surgery

  This project tests two cycles of neoadjuvant immunochemotherapy (tislelizumab with paclitaxel plus cisplatin or carboplatin) in people with locally advanced oral or oropharyngeal squamous cell carcinoma to see tumor response and survival outcomes.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT07133958

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.