Treatment for advanced gum disease using chitosan products

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of a non-surgical treatment for advanced periodontal disease using a chitosan brush and chitosan gel. Patients who have not responded well to conventional treatments will receive mechanical debridement combined with the application of Labrida GeliX Chitosan gel. The primary objective is to measure the reduction in periodontal inflammation and attachment loss over a period of 6 to 12 months. The study will compare outcomes between a test group receiving the chitosan treatment and a control group.

Why it matters

Who can join: the full rules

Inclusion criteria:

Patients with at least 3 teeth but less than 8 teeth with advanced periodontal attachment loss.

Clinical Attachment Loss (CAL) ≥5 mm, probing pocket depth (PPD) ≥5mm and ≤8 mm and inflammation as demonstrated by a modified Bleeding on Probing (BoP) grade 2 (line) or 3 ("spontaneous").

Exclusion criteria:

* Ongoing radiotherapy, ongoing chemotherapy, pregnant or nursing patients, prosthetic factors making access to clinical measurements impossible
* Poor oral hygiene with plaque at \>20% of the surfaces
* Periodontal pockets reaching to the apex of teeth.
* Teeth with active peri-apical pathology
* Teeth with root resorption as seen on radiographs
* Teeth with prosthodontic technical complications should be excluded or treated before inclusion (e.g., overhangs, open contacts with food impaction)
* Teeth with pockets from other reasons than periodontal disease
* Teeth with traumatic occlusion should be excluded or treated before inclusion (i.e., fremitus)
* Patients diagnosed with Periodontal disease grade C i.e., rapid rate of progression
* Sites in direct proximity with site(s) where patient places snuff (Copenhagen) will be excluded

Where it's running

• Bjerke tannmedisin
  Oslo, Norway Recruiting

Study contacts

• Study coordinator: Johan C Wohlfahrt, PhD
• Email: casparwohlfahrt@gmail.com
• Phone: +4747905629

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• JAK1 and JAK2 activation in healthy versus inflamed gums

  We will test whether the JAK1 and JAK2 immune-signaling pathways are more active in adults with periodontitis than in adults with healthy gums.

  Recruiting University of Chile · Santiago, Metropolitan Region · NCT07536204

• Hyaluronic acid and octenidine gel with non-surgical gum treatment

  This pilot will test whether adding a hyaluronic acid and octenidine gel to non-surgical periodontal treatment helps adults with advanced periodontitis heal faster and reduce inflammation.

  Recruiting at 2 sites Queen Mary University of London · London and 1 other locations · NCT06522438

• Comparing three types of papilla incision techniques in periodontal surgery

  This study is testing three different ways to make cuts in the gums during periodontal surgery to see which method works best for treating gum disease.

  Recruiting Universidad de Murcia · Murcia, Murcia · NCT06428149

• Treatment of gum defects using hyaluronic acid and polynucleotides

  This study is testing if adding a special gel to gum surgery helps people with gum disease heal better and faster.

  Recruiting at 2 sites Queen Mary University of London · London and 1 other locations · NCT06309719

• Comparing three techniques for periodontal reconstruction

  This study tests three different surgical methods for fixing gum issues in people with periodontitis to see which one works best for improving their dental health.

  Recruiting Universidad de Murcia · Murcia · NCT03997552

• Dental Loupes vs. Dental Operating Microscope for Non-Surgical Periodontal Treatment

  This study tests whether using dental loupes or a dental operating microscope makes non-surgical periodontal cleaning more effective for adults with periodontitis.

  Recruiting Saglik Bilimleri Universitesi · Ankara and 2 other locations · NCT07822269

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.