Tracking long-term health and family effects after intensive care in the DACH region
Post-Intensive Care Syndrome - Multicentre Prospective Registry Database of the DACH Region
This project will try to follow adults who spent more than 72 hours in the ICU and their families to see which factors lead to lasting physical, cognitive, or mental health problems.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 4 sites (Vienna, State of Vienna and 3 other locations) |
| Trial ID | NCT07290712 on ClinicalTrials.gov |
What this trial studies
This is a prospective multicentre registry that collects clinical data during ICU stays and follows patients and their relatives for up to five years using standardized questionnaires and blood samples. The protocol is organized into six modules covering ICU data, staged post-ICU follow-ups, environmental and psychiatric factors, translational biological sampling, and family-system effects. The primary focus is on improving diagnostic and therapeutic strategies, while secondary aims include identifying risk factors, measuring impairment severity, and exploring underlying biological mechanisms. Recruitment occurs at several major academic centers in the DACH region with both in-person and remote follow-up elements.
Who should consider this trial
Good fit: Adults who had an ICU stay longer than 72 hours (with capacity for consent or appropriate proxy consent) and their close relatives are the intended participants.
Not a fit: People under 18, patients receiving end-of-life care at screening, and those with very short ICU stays are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the registry could help clinicians identify patients and families at high risk for PICS and target follow-up or interventions to reduce long-term disability.
How similar studies have performed: Previous observational cohorts and registries have documented high rates of PICS and some risk factors, but large multicentre registries combining clinical, family, and biological data are still relatively uncommon.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with an ICU stay longer than 72 hours will be included Exclusion Criteria: * Age \< 18 years old * Patients who receive end-of-life care at the time of screening
Where this trial is running
Vienna, State of Vienna and 3 other locations
- Medical University of Vienna — Vienna, State of Vienna, Austria (Recruiting)
- Universitätsklinikum Augsburg — Augsburg, Bavaria, Germany (Not_yet_recruiting)
- Universitätsklinikum Würzburg — Würzburg, Bavaria, Germany (Not_yet_recruiting)
- Charité - Universitätsmedizin Berlin — Berlin, State of Berlin, Germany (Not_yet_recruiting)
Study contacts
- Principal investigator: Stefan J Schaller, MD — Medical University of Vieanna
- Study coordinator: PICS-DACH Steering Committee
- Email: pics-dach-sc@listserv.muv.ac.at
- Phone: +4314040041020
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.