Clinical trial Recruiting at 1 site Interventional Ages 18 to 70

Olfactory training for patients with smell disorders in Hong Kong

Official title: Effect of Olfactory Training on Olfactory Dysfunction Patients in Hong Kong Population

Run by Pamela Youde Nethersole Eastern Hospital · NCT05364125 · Data updated 2026-11-12

This study is testing if a special smell training program can help people in Hong Kong with smell disorders feel better and improve their sense of smell.

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Quick facts

Study typeInterventional
Ages18 Years to 70 Years
SexAll
Enrollment80 (estimated)
SponsorPamela Youde Nethersole Eastern Hospital
Academic / other
Locations1 site (Hong Kong)
StatusRecruiting
StartedJuly 1, 2022
Main results expectedJune 30, 2027
Study endsJune 30, 2027
Registry record updatedJune 3, 2025
Trial IDNCT05364125 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals with olfactory dysfunction lasting more than 6 months but less than 5 years.

Probably not a fit

Patients with a history of significant head injury, brain surgery, nasal surgery, active nasal or neurological diseases, or those under 18 years old will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of olfactory training for patients suffering from various types of olfactory dysfunction, particularly sensorineural causes. The study employs a prospective double-blinded randomized control design, where participants will be assessed for their smell capabilities using standardized tests and will be randomly assigned to either an olfactory training group or a control group. The training involves the use of aromatic substances delivered through an electronic diffuser, aiming to improve patients' olfactory function and quality of life. The trial is set to run from July 2022 to June 2024, focusing on a local population in Hong Kong.

Why it matters

Potential benefit: If successful, this study could significantly improve the sense of smell and overall quality of life for patients with olfactory dysfunction.

How similar studies have gone: Previous studies have shown success with olfactory training for COVID-19 related olfactory dysfunction, but this approach for other non-COVID-19 causes is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Olfactory dysfunction \> 6 months and \< 5 years

Exclusion Criteria:

* History of significant head injury (fracture, ICH)
* History of brain surgery
* History of nasal surgery
* Active nasal disease
* Active neurological disease
* Poor premorbid status/ non-communicable patients
* Mentally incompetent patients
* \<18 years' old
* Pregnancy
* Hypersensitivity to the aromatic substance.

Where it's running

  • Pamela Youde Nethersole Eastern Hospital
    Hong Kong, Hong Kong
    Recruiting

Study contacts

  • Principal investigator: Kai Chuen Fergus Wong, FRCSEd(ORL) — Pamela Youde Nethersole Eastern Hospital
  • Study coordinator: Kai Chuen Fergus Wong, FRCSEd(ORL)
  • Email: wkc568@ha.org.hk
  • Phone: 64600771

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.