Olfactory training for patients with smell disorders in Hong Kong
Official title: Effect of Olfactory Training on Olfactory Dysfunction Patients in Hong Kong Population
Run by Pamela Youde Nethersole Eastern Hospital · NCT05364125 · Data updated 2026-11-12
This study is testing if a special smell training program can help people in Hong Kong with smell disorders feel better and improve their sense of smell.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Pamela Youde Nethersole Eastern Hospital Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | July 1, 2022 |
| Main results expected | June 30, 2027 |
| Study ends | June 30, 2027 |
| Registry record updated | June 3, 2025 |
| Trial ID | NCT05364125 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals with olfactory dysfunction lasting more than 6 months but less than 5 years.
✕Probably not a fit
Patients with a history of significant head injury, brain surgery, nasal surgery, active nasal or neurological diseases, or those under 18 years old will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of olfactory training for patients suffering from various types of olfactory dysfunction, particularly sensorineural causes. The study employs a prospective double-blinded randomized control design, where participants will be assessed for their smell capabilities using standardized tests and will be randomly assigned to either an olfactory training group or a control group. The training involves the use of aromatic substances delivered through an electronic diffuser, aiming to improve patients' olfactory function and quality of life. The trial is set to run from July 2022 to June 2024, focusing on a local population in Hong Kong.
Why it matters
Potential benefit: If successful, this study could significantly improve the sense of smell and overall quality of life for patients with olfactory dysfunction.
How similar studies have gone: Previous studies have shown success with olfactory training for COVID-19 related olfactory dysfunction, but this approach for other non-COVID-19 causes is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Olfactory dysfunction \> 6 months and \< 5 years Exclusion Criteria: * History of significant head injury (fracture, ICH) * History of brain surgery * History of nasal surgery * Active nasal disease * Active neurological disease * Poor premorbid status/ non-communicable patients * Mentally incompetent patients * \<18 years' old * Pregnancy * Hypersensitivity to the aromatic substance.
Where it's running
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Pamela Youde Nethersole Eastern Hospital
Hong Kong, Hong Kong Recruiting
Study contacts
- Principal investigator: Kai Chuen Fergus Wong, FRCSEd(ORL) — Pamela Youde Nethersole Eastern Hospital
- Study coordinator: Kai Chuen Fergus Wong, FRCSEd(ORL)
- Email: wkc568@ha.org.hk
- Phone: 64600771
Similar studies
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We’re testing whether a smartphone-enabled, wearable-guided activity plan can be safely and practically used by adults 40 and over who have a reduced sense of smell and low activity, to see if people can stick with it and accept it.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.