Tilt-table provocation for adults with vasovagal syncope
Official title: Multicenter RCT to Assess the Clinical Benefit of Provocation on Tilt-table in SYNCope Patients, TiltSYNC-trial
Run by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · NCT07459478 · Data updated 2026-11-12
This trial will test whether adding tilt-table provocation to biofeedback and standard care helps adults with confirmed or highly likely vasovagal syncope avoid future fainting.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 238 (estimated) |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam) |
| Status | Recruiting |
| Started | October 30, 2025 |
| Main results expected | June 1, 2027 |
| Study ends | March 1, 2028 |
| Registry record updated | March 11, 2026 |
| Trial ID | NCT07459478 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (age >18) judged to have certain or highly likely vasovagal syncope after standard diagnostic evaluation, who can provide informed consent and have no contraindication to tilt-table testing, are eligible.
✕Probably not a fit
Patients under 18, those with other forms of reflex syncope, pre-syncope only, learning disabilities, contraindications to tilt-table testing, or those already diagnosed and referred for specific treatments are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a multicenter randomized controlled comparison of two management strategies for adults judged to have certain or highly likely vasovagal syncope after guideline-based evaluation. One group receives biofeedback plus standard care with tilt-table provocation, and the other group receives biofeedback with standard care without tilt-table provocation. Patients are randomized to one of the two approaches and followed for clinical outcomes related to syncope recurrence and symptom burden. The trial addresses a current clinical equipoise because tilt-table testing is widely used but lacks robust randomized evidence for benefit.
Why it matters
Potential benefit: If successful, adding tilt-table provocation could reduce recurrent fainting and help tailor treatment for adults with vasovagal syncope.
How similar studies have gone: Tilt-table testing is commonly used in practice but randomized controlled evidence comparing provocation versus no provocation is lacking, and no definitive RCTs have established clear benefit.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients \>18 years of age with certain/highly likely vasovagal syncope after the guideline based syncope evaluation Exclusion Criteria: * Those aged \<18 years * Any patient diagnosed with another form of reflex syncope other than vasovagal syn-cope * Contraindication for tilt table testing at the discretion of the responsible physician * Those with a learning disability * Those presenting with pre-syncope and not with complete loss of consciousness * Those who are unwilling to provide informed consent * Those already diagnosed prior to evaluation who are referred for specific treatment op-tions
Where it's running
-
Amsterdam UMC
Amsterdam, Netherlands Recruiting
Study contacts
- Principal investigator: Frederik J de Lange, MD, PhD — AmsterdamUMC
- Study coordinator: Thomas T Boel, MD
- Email: t.t.boel@amsterdamumc.nl
- Phone: 31 20 5669111
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.