Thyroid artery embolization to relieve compressive goiters.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-center interventional cohort that will perform thyroid artery embolization (TAE) in adults with symptomatic compressive nodular goiters who are ineligible for or prefer not to have surgery or ablation. Patients will be recruited in outpatient clinics by endocrinologists or otolaryngologists using convenience sampling and followed with standardized imaging and clinical assessments to measure symptom relief and safety over time. Inclusion requires TI-RADS 1–4 and specific Bethesda cytology criteria (Bethesda I/III on two biopsies or Bethesda II on one), and the study excludes TI-RADS 5, Bethesda IV–VI, uncontrolled severe hyperthyroidism, and major comorbidities that preclude endovascular procedures. There is no comparative control group; outcomes will be compared with historical data and prior retrospective series to better define expected results and safety profiles.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient with compressive symptoms or significant tracheal or oesophageal compression at risk of causing symptoms attributed to a goiter AND
* Ineligible for surgery/ablative treatments or preference for TAE over other treatments AND
* TiRADS category 1, 2, 3 or 4 AND
* Bethesda categories I or III on 2 different biopsies OR Bethesda II on one biopsy AND
* Patient at least 18 years old.

Exclusion Criteria:

* Comorbidities precluding endovascular procedure OR
* TiRADS category 5 OR
* Bethesda categories IV, V, VI on biopsy OR
* Refusal of the patient to participate OR
* Uncontrolled severe hyperthyroidism OR
* Minor patient.

Where it's running

• Centre Hospitalier Universitaire de Sherbrooke
  Sherbrooke, Quebec, Canada Recruiting

Study contacts

• Study coordinator: Laurent Fradet, MD FRCSC
• Email: Laurent.Fradet@USherbrooke.ca
• Phone: +1-819-346-1110

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.