Adding urea to the final dialysis fluid

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 1/2 interventional approach adds measured amounts of urea (using Ure-Na 15 g tablets) to the dialysate during hemodialysis so the dialysate urea concentration is kept about 15–40 mg/dL lower than the patient’s serum value. The calculation of how much urea to add is based on the dialysis system and the patient’s serum urea concentration. The aim is to allow aggressive removal of potassium and correction of metabolic acidosis while preventing a rapid drop in serum osmolality that can cause disequilibrium syndrome. Patients’ labs, vital signs, and symptoms are closely monitored throughout treatment to guide adjustments and safety assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Serum Urea \> 120
* Serum Potassium \> 5.5 or serum CO2 \< 15 or need for aggressive dialysis due to toxic ingestion
* need for dialysis

Exclusion Criteria:

* Pediatric
* need for CRRT

Where it's running

• Zuckerberg San Francisco General Hospital
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Ramin Sam, MD — Zuckerberg San Francisco General- UCSF
• Study coordinator: Ramin Sam, MD
• Email: ramin.sam@ucsf.edu
• Phone: 6282066605

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Sodium bicarbonate for critically ill patients with metabolic acidosis and AKI

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• Veverimer for metabolic acidosis in adults with chronic kidney disease.

  This 26-week trial will test whether veverimer can raise bicarbonate levels and improve outcomes in adults with moderate-to-severe CKD and metabolic acidosis.

  Recruiting at 27 sites Phase 3 Renibus Therapeutics, Inc. · Chula Vista, California and 27 other locations · NCT07355062

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.