Testing a blood test to predict response to cancer immunotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to evaluate the effectiveness of the Episwitch CiRT® test, which uses blood-based 3D genome conformation mapping to predict how patients with stage III and IV cancer will respond to PD-(L)-1 checkpoint inhibitors. Patients selected for this test will be monitored for their treatment responses over a six-month period, with data collected on various health outcomes and social determinants. The study will compare predicted responses to actual treatment outcomes, providing insights into the test's predictive capabilities.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 18 years of age or older
2. Stage III or IV cancer
3. Selected by their healthcare provider to receive the Episwitch CiRT® test according to the current evidence-based schedule (per protocol) as part of their standard of practice.
4. ECOG performance status ≤ 2
5. Clinically eligible for ICI therapy
6. Able to read, understand and provide written informed consent.
7. Willing and able to comply with the study requirements

Exclusion Criteria:

1. Pregnant or breastfeeding
2. History of bone marrow or organ transplant
3. Contra indication for receiving Immune Check Point inhibitor.

Where it's running

• Eastern Connecticut Hematology and Oncology
  Norwich, Connecticut, United States Recruiting
• Cancer Center of Middle Georgia
  Dublin, Georgia, United States Recruiting
• Carolina Blood and Cancer Care Associates
  Rock Hill, South Carolina, United States Recruiting

Study contacts

• Study coordinator: Ryan Mathis, MD
• Email: ryan.mathis@myobdx.com
• Phone: 888-200-3361

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.