Clinical trial Recruiting at 1 site Interventional Ages 18 and up

TCAF versus MTUN with soft tissue grafts for a single gum recession in the lower premolar area

Official title: An RCT Comparing Tunneled Coronally Advanced Flap (TCAF) and Modified Tunnel Technique (MTUN) in Combination With a Soft Tissue Graft for Single Recession Coverage

Run by University Hospital, Ghent · NCT07158541 · Data updated 2026-11-12

This compares whether a tunneled coronally advanced flap (TCAF) or a modified tunnel (MTUN), each combined with a connective tissue graft, gives better root coverage for adults with a single gum recession in the lower premolar area.

More Gingival Recession trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment24 (estimated)
SponsorUniversity Hospital, Ghent
Academic / other
Locations1 site (Ghent, Oost-Vlaanderen)
StatusRecruiting
StartedAugust 25, 2025
Main results expectedDecember 31, 2037
Study endsDecember 31, 2037
Registry record updatedSeptember 16, 2025
Trial IDNCT07158541 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 or older in good general health with good oral hygiene and a single gingival recession in the premandible who are non-smokers and not pregnant are ideal candidates.

Probably not a fit

Smokers, pregnant women, people with multiple or widespread recessions, or those with poor oral hygiene or significant systemic disease are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial enrolls adults with a single gingival recession in the premandible and good oral hygiene to compare two surgical techniques: tunneled coronally advanced flap (TCAF) and modified tunnel (MTUN), both paired with a connective tissue graft. Participants are randomly assigned to the test (TCAF) or control (MTUN) group and followed for short- and long-term measures of root coverage. Primary outcomes are average root coverage at specified follow-up times, with secondary outcomes including sensitivity, aesthetics, and tissue thickness. Smokers and pregnant women are excluded, and procedures are performed at the Department of Periodontology and Implantology of Ghent University.

Why it matters

Potential benefit: If one technique provides better root coverage, patients could experience less tooth sensitivity, improved appearance, and easier oral hygiene for the treated tooth.

How similar studies have gone: Both tunnel and coronally advanced flap techniques combined with connective tissue grafts have shown good root coverage in prior reports, but randomized head-to-head comparisons of TCAF versus MTUN are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* at least 18 years old
* good oral hygiene
* presence of one recession in the premandible
* good general health

Exclusion Criteria:

* smoker
* pregnant women (assessed at each visit; if the patient appears pregnant during follow-up, x-rays will not be taken)

Where it's running

  • Department of Periodontology and Implantology of Ghent University
    Ghent, Oost-Vlaanderen, Belgium
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.