Effects of Low-Level Laser Therapy and Hyaluronic Acid After Free Gingival Graft

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, parallel-group study compares three approaches after free gingival graft surgery: the graft alone, graft plus 810-nm diode laser therapy, and graft with hyaluronic acid gel. Participants are adults with inadequate keratinized gingiva in the mandibular anterior region and are followed for six months to assess graft shrinkage, wound healing, clinical periodontal outcomes, pain, and quality of life. The laser group receives light treatment on the day of surgery and on postoperative days 1, 3, 7, and 14; the hyaluronic acid group receives gel application in addition to surgery. Outcomes include donor- and recipient-site pain, epithelialization, and standard periodontal measurements such as recession depth and keratinized tissue width. The study aims to determine whether these adjuncts improve healing, esthetics, and patient-reported outcomes compared with grafting alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Voluntary participation and provision of written informed consent
* Systemically healthy adults aged 18 years or older
* Non-smokers
* No known drug allergies
* Not pregnant or breastfeeding
* Presence of Cairo RT1 or RT2 gingival recession in the mandibular anterior region
* Keratinized tissue width of less than 2 mm at the planned grafting site
* Plaque Score below 20% and Bleeding on Probing score below 20%
* Vital teeth in the surgical area

Exclusion Criteria:

* Current use of medications that may interfere with wound healing or are contraindicated for surgical procedures
* Pregnancy or breastfeeding
* Ongoing orthodontic treatment in the affected region
* History of previous periodontal surgery in the study area
* Presence of active periodontal disease
* Probing pocket depth greater than 3 mm in the involved teeth

Where it's running

• Altınbaş University Dental Hospital
  Istanbul, Bakırköy, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Deniz BARLAS, PHD in periodontology
• Email: denizbarlas04@gmail.com
• Phone: +905301454418

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• TCAF versus MTUN with soft tissue grafts for a single gum recession in the lower premolar area

  This compares whether a tunneled coronally advanced flap (TCAF) or a modified tunnel (MTUN), each combined with a connective tissue graft, gives better root coverage for adults with a single gum recession in the lower premolar area.

  Recruiting University Hospital, Ghent · Ghent, Oost-Vlaanderen · NCT07158541

• CAF versus TCAF with connective tissue grafts for multiple maxillary gum recessions

  This comparison will test whether coronally advanced flap (CAF) or tunneled coronally advanced flap (TCAF), each combined with a connective tissue graft, provides better root coverage for adults with multiple gum recessions in the upper jaw.

  Recruiting University Hospital, Ghent · Ghent, Oost-Vlaanderen · NCT07158528

• Comparing two gum‑repositioning surgeries with connective tissue grafts for multiple recessions in the lower front teeth

  This trial will test whether the coronally advanced flap (CAF) or the tunneled coronally advanced flap (TCAF), both with connective tissue grafts, gives better root coverage for people with multiple gum recessions on their lower front teeth.

  Recruiting University Hospital, Ghent · Ghent, Oost-Vlaanderen · NCT06940050

• Compare Fibro-Gide collagen membrane versus connective tissue graft to cover multiple areas of gum recession

  This trial tests whether a synthetic collagen matrix (Fibro-Gide) can replace tissue taken from the roof of the mouth to cover multiple gum recession defects in adults.

  Recruiting at 2 sites The European Research Group on Periodontology (ERGOPerio) · Florence and 1 other locations · NCT07083050

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.