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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Comparing two gum‑repositioning surgeries with connective tissue grafts for multiple recessions in the lower front teeth

Official title: An RCT Between Coronally Advanced Flap (CAF) and Tunneled Coronally Advanced Flap (TCAF) in Combination With Soft Tissue Graft for Multiple Recession Coverage.

Run by University Hospital, Ghent · NCT06940050 · Data updated 2026-11-12

This trial will test whether the coronally advanced flap (CAF) or the tunneled coronally advanced flap (TCAF), both with connective tissue grafts, gives better root coverage for people with multiple gum recessions on their lower front teeth.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment34 (estimated)
SponsorUniversity Hospital, Ghent
Academic / other
Locations1 site (Ghent, Oost-Vlaanderen)
StatusRecruiting
StartedApril 30, 2025
Main results expectedDecember 31, 2036
Study endsDecember 31, 2037
Registry record updatedOctober 1, 2025
Trial IDNCT06940050 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (≥18) in good general health and with good oral hygiene who have at least two adjacent recessions in the lower front (premandibular) region and who are non-smokers and not pregnant.

Probably not a fit

Patients who smoke, are pregnant, have poor oral hygiene, significant systemic health issues, or only isolated single recessions may not benefit or may be ineligible.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial at Ghent University compares two surgical approaches—CAF and TCAF—each combined with a connective tissue graft to treat multiple adjacent gingival recessions in the premandible. Adult patients with at least two recessions, good oral hygiene, and good general health are randomized to one of the two techniques and followed over short- and long-term visits to measure root coverage. Key exclusions include current smoking and pregnancy. The main outcome is average root coverage achieved with each technique, with secondary interest in symptom relief, aesthetics, and periodontal stability.

Why it matters

Potential benefit: If successful, the better technique could provide more predictable root coverage, reducing tooth sensitivity, improving appearance, and making oral hygiene easier.

How similar studies have gone: Both CAF and tunnel techniques combined with connective tissue grafts are well established and have shown good root coverage in prior studies, while the combined TCAF approach is a more recent variation with less long‑term data.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* at least 18 years old
* good oral hygiene
* presence of at least 2 recessions in the premandible
* good general health

Exclusion Criteria:

* smoker
* pregnant women (assessed at each visit; if the patient appears pregnant during follow-up, x-rays will not be taken)

Where it's running

  • Department of Periodontology and Implantology of Ghent University
    Ghent, Oost-Vlaanderen, Belgium     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.