Structured nutrition plus exercise to improve fat and muscle in older adults with obesity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial compares a structured nutrition plan combined with supervised exercise to usual diet and activity in 80 adults aged 50+ with obesity and insulin resistance. Participants receive all meals for 12 weeks and exercise under supervision three times weekly at the Center. Outcomes include body composition, lower-extremity function, muscle strength, and daily caloric intake. Researchers will assess changes in fat mass, muscle function, and energy deficit to determine the added value of the dietary intervention on physical health. The study aims to address sarcopenic obesity by targeting both muscle quality and adiposity through lifestyle changes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \> 50 years.
2. Body mass index (BMI) ≥ 30 kg/m2.
3. Homeostatic model assessment of insulin resistance ≥ 3.
4. Mini-Mental State Examination (MMSE) \> 25.
5. Geriatric Depression Scale-15 (GDS-15) \< 9.
6. Sedentary (less than 90 minutes/week of moderate to vigorous activity).
7. Ability to provide written informed consent.

Exclusion Criteria:

1. Diagnosis of cancer (received within five years) or diabetes (type 1 and 2), or significant musculoskeletal, or cardiovascular, or hepatic, or renal, disease or dysfunction.
2. Clinically significant gastrointestinal malabsorption syndromes such as chronic diarrhea, celiac disease, or clinically significant abnormal laboratory markers.
3. Fluctuation in body weight \> 3 kg in the preceding two months
4. Condition that impedes testing of the study hypothesis or makes it unsafe to exercise or consume the study foods.

Where it's running

• Pennington Biomedical Research Center
  Baton Rouge, Louisiana, United States Recruiting

Study contacts

• Principal investigator: Candida J Rebello, PhD, RD — Pennington Biomedical Research Center
• Study coordinator: Candida J Rebello, PhD, RD
• Email: Candida.Rebello@pbrc.edu
• Phone: 12257633159

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.