Role of Estradiol and Progesterone on Appetite and Energy Balance in Young Men
Official title: The Role of Estradiol and Progesterone on Appetite Regulation and Energy Balance
Run by Wilfrid Laurier University · NCT07620587 · Data updated 2026-11-12
This study tests whether estradiol and progesterone affect appetite and energy balance in healthy young men.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 30 Years |
| Sex | Men only |
| Enrollment | 60 (estimated) |
| Sponsor | Wilfrid Laurier University Academic / other |
| Locations | 1 site (Waterloo, Ontario) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | August 31, 2028 |
| Study ends | August 31, 2028 |
| Registry record updated | June 2, 2026 |
| Trial ID | NCT07620587 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy, non-smoking men aged 18-30 who are recreationally active and willing to take part in a 13-day hormone-supplement protocol.
✕Probably not a fit
Individuals with metabolic disease, obesity (BMI ≥ 30), thromboembolic risk, liver dysfunction, or hormone sensitivities may not benefit from or be eligible for this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial investigates the effects of estradiol, progesterone, both hormones, or placebo on appetite hormones, perceived appetite, energy intake, and energy expenditure. Over 13 days, participants receive daily oral hormone supplementation and complete two in-lab sessions with either high-intensity interval training or rest, followed by an ad-libitum meal. Free-living energy intake and thigh-worn accelerometry are used to assess energy balance on surrounding days. The trial aims to clarify the individual and combined roles of these ovarian hormones in energy regulation in healthy, recreationally active male participants.
Why it matters
Potential benefit: If successful, findings could improve understanding of how ovarian hormones influence hunger, intake, and energy expenditure, potentially informing obesity and weight-management strategies.
How similar studies have gone: Previous research has explored hormone effects on appetite in various populations, with mixed outcomes; this study adds a controlled, male-focused, multi-arm design to existing evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ages 18-30 years * deemed healthy using Canadian Society for Exercise Physiology Get Active Questionnaire (CSEP-GAQ) * non-smoking Exclusion Criteria: * failure to meet inclusion criteria * contraindications to exercise as indicated by the (CSEP-GAQ) * hypersensitivity or allergy to estradiol, progesterone, cellulose, or capsule components * having been diagnosed with any metabolic disease (ie. diabetes, metabolic syndrome) or current diagnosis of overweight/obesity (BMI \> 30.0) * personal of family history of stroke or thrombotic (blood clot) disease, blood clot disorder, venous or arterial thromboembolic disease, or any possible blood clotting disease * currently taking anticoagulants, antidiabetic medications, cyclosporine, antihypertensives, and CYP3A4 inducers or inhibitors (e.g., rifampin, ketoconazole, St. John's Wort) * known liver dysfunction or liver disease * history of ophthalmic vascular disease * hormone-dependent malignancies or previous diagnosis of cancer * recent major surgery (within \~6 months) * prolonged use of a cast or presence of immobility deeming inability to exercise, diagnosis of inflammatory disorders (ie. rheumatoid arthritis, celiac disease, inflammatory bowel disease) * history of sensitivity to or extreme nausea/vomiting or any gastrointestinal disorder * diagnosis of mental health or mood disorder * presence of abnormal eating behaviours as assessed by the Food Cravings State Questionnaire and the Three Factor Eating Questionnaire * diagnosed or presence of porphyria or classical migraines
Where it's running
-
Energy Metabolism Research Laboratory
Waterloo, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Tom J Hazell, PhD — Wilfrid Laurier University
- Study coordinator: Jessica Tucker, MKin, PhD Candidate
- Email: tuck5010@mylaurier.ca
- Phone: 519-884-1970
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.