Exercise Self-Efficacy, Body Composition, and Activity in Men with Low Testosterone

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines the relationships between body composition, physical activity, and exercise self-efficacy in men with hypogonadism who are receiving testosterone replacement therapy. It seeks to determine if exercise self-efficacy mediates the link between body composition and activity levels, considering the time-dependent effects of TRT on mood, energy, and motivation. Participants are adult men with biochemically confirmed hypogonadism on TRT, able to read Turkish, and without major comorbidities that limit activity. The study is conducted at Turkish sites affiliated with Hacettepe University and partner clinics. Interventions are not specified, and eligibility focuses on hormonal status, treatment response, and ability to participate in physical activity assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Confirmed diagnosis of male hypogonadism (primary or secondary; biochemically verified with a morning serum total testosterone level \<300 ng/dL).
* Currently undergoing TRT with observed partial or complete symptom remission, evaluated as treatment-responsive by the clinician.
* Aged 18 years or older.
* Ability to read and write in Turkish.
* Voluntary agreement to participate and signature on the informed consent form.

Exclusion Criteria:

* Neurological, orthopedic, or cardiopulmonary conditions independent of hypogonadism that restrict physical activity capacity.
* Diagnosed psychiatric disorders directly impacting exercise self-efficacy and physical activity (e.g., major depressive disorder, psychosis).
* Concomitant endocrine disorders significantly affecting body composition, including uncontrolled or complicated diabetes mellitus (HbA1c \>8.0% or presence of diabetic nephropathy, neuropathy, retinopathy) or biochemically unverified euthyroid state in thyroid disease.
* Presence of conditions preventing bioelectrical impedance analysis (e.g., implanted cardiac devices/pacemakers).
* Visual or cognitive impairments preventing the reading and completion of study questionnaires.
* Chronic inflammatory conditions directly affecting body composition and physical capacity (e.g., chronic kidney disease, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis).

Where it's running

• Bingol University Faculty of Physical Therapy and Rehabilitation
  Bingoel, Turkey (Türkiye) Recruiting
• Malatya Training and Research Hospital
  Malatya, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Aybüke Fanuscu, Pt, PhD — Bingol University
• Study coordinator: Emine Şener Aydın, MD
• Email: dreminesener@windowslive.com
• Phone: +904222118019

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.