Stellate ganglion block to help POTS symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, single-center study assigns 20 adults with POTS to receive either a stellate ganglion block or a sham saline injection, with ropivacaine used in the block. The goal is to measure immediate and longer-term changes in heart rate, sympathetic activity markers, and overall POTS symptoms. Participants will undergo three follow-up visits to assess durability of any effects and safety. The trial is led by Stanford University and will compare the active intervention to a saline control in a controlled setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (\>18 years of age) diagnosed with POTS
* Ability to provide informed consent
* Ability to comply with 3 follow up visits
* English speaking and capable of signing informed consent and complying with protocol requirements

Exclusion Criteria:

* Allergy to local anesthetics
* Severe coagulopathy
* History of or currently being treated for clinically significant ongoing cardiac arrhythmia, heart failure, myocarditis, pulmonary embolism requiring anticoagulation, pulmonary fibrosis or other pulmonary diagnosis that in the investigator's opinion may contribute to symptoms of POTS
* Inability to maintain a stable medication regiment for the duration of the study

Where it's running

• Stanford University School of Medicine
  Stanford, California, United States Recruiting
• Stanford University
  Stanford, California, United States Recruiting

Study contacts

• Study coordinator: Anna Maria Bombardieri, MD, PhD
• Email: abomba@stanford.edu
• Phone: 3143269107

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.