Effects of CO2 on heart rate and symptoms in POTS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research investigates the impact of increased carbon dioxide levels on heart rate and symptoms in patients with Postural Orthostatic Tachycardia Syndrome (POTS). The study utilizes the RespirAct™ system to control and monitor gas concentrations during inhalation, aiming to determine the optimal CO2 levels that may alleviate orthostatic symptoms. By examining the relationship between hypercapnia and orthostatic tolerance, the researchers hope to provide a new therapeutic approach for managing POTS. The study will include participants aged 18-60 diagnosed with POTS who can travel to the University of Calgary for testing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Physician diagnosis of Postural Tachycardia Syndrome (POTS)
* Age 18-60 years
* Male and Female
* Non - smokers.
* Able and willing to provide informed consent.
* Ability to travel to Libin Cardiovascular Institute of Alberta Autonomic Testing Lab at the University of Calgary, Calgary, AB.

Exclusion Criteria:

* Overt cause for postural tachycardia, i.e., acute dehydration
* Participants with somatization or severe anxiety symptoms will be excluded
* Pregnant
* Inability to tolerate mask for the duration of the study
* Subjects who require portable oxygen at rest or with exercise
* Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
* Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies.

Where it's running

• University of Calgary
  Calgary, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Satish R Raj, MD, MSCI — University of Calgary, Cardiac Science
• Study coordinator: Shaun Ranada, BSc
• Email: shaun.ranada@ucalgary.ca
• Phone: 403-210-6152

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Stellate ganglion block to help POTS symptoms

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• Understanding how the brain communicates in young people with Postural Tachycardia Syndrome

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• Assessing counterpressure maneuvers for preventing fainting in children

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  Recruiting Simon Fraser University · Vancouver, British Columbia · NCT05555771

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.