Investigating antibodies in patients with Postural Tachycardia Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to determine if patients with Postural Tachycardia Syndrome (POTS) have a higher percentage of functional antibodies to adrenergic receptors compared to healthy control subjects. The study will involve patients aged 18-60 who have been diagnosed with POTS and will utilize a rat cremaster artery assay to assess the contractile activity of their sera. The findings could provide insights into the autoimmune aspects of POTS and potentially lead to new treatment approaches.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who have been previously diagnosed with POTS
* Control subjects (patients not diagnosed with POTS)
* Age between 18 - 60 years
* Males and Females (Give that \>80% of POTS patients are female, we will attempt to enroll a similar percentage of female control subjects)
* Able and willing to provide consent

Exclusion Criteria:

* Smokers
* Overt cause for postural tachycardia, i.e., acute dehydration
* Significant cardiovascular, pulmonary, hepatic, or hematological disease by history or prior testing
* Highly trained athletes
* Subjects with somatization or severe anxiety symptoms will be excluded
* Use of drospirenone (a spironolactone analogue) containing oral contraceptive agent
* Hypertension defined as supine resting BP\>145/95 mmHg off medications or needing antihypertensive medication
* Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule
* Unable to give informed consent

Where it's running

• University of Calgary
  Calgary, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Satish R Raj, MD, MSCI — University of Calgary
• Study coordinator: Satish R Raj, MD, MSCI
• Email: autonomic.research@ucalgary.ca
• Phone: 403-210-6152

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Stellate ganglion block to help POTS symptoms

  This study tests whether a stellate ganglion block can improve symptoms and heart rate in adults with Postural Tachycardia Syndrome compared with a sham injection.

  Recruiting at 2 sites Stanford University · Stanford, California and 1 other locations · NCT06953661

• Understanding how the brain communicates in young people with Postural Tachycardia Syndrome

  This study is testing how young people with Postural Tachycardia Syndrome understand visual information to see how their brain communicates differently compared to healthy peers.

  Recruiting Virginia Commonwealth University · Richmond, Virginia · NCT05618054

• Registry for Inappropriate Sinus Tachycardia and Postural Tachycardia Syndrome treatments

  This study is collecting information on the safety and effectiveness of AtriCure devices used to treat people with Inappropriate Sinus Tachycardia or Postural Tachycardia Syndrome.

  Recruiting at 15 sites AtriCure, Inc. · Loma Linda, California and 14 other locations · NCT05107635

• Observing autonomic neuropathies and Ehlers Danlos syndromes over time

  This study is trying to understand how autonomic neuropathies and Ehlers Danlos syndromes change over time in patients compared to healthy individuals.

  Recruiting RWTH Aachen University · Aachen, North Rhine-Westphalia · NCT04310644

• Effects of CO2 on heart rate and symptoms in POTS patients

  This study tests if breathing in higher levels of carbon dioxide can help improve heart rate and symptoms for people with Postural Orthostatic Tachycardia Syndrome (POTS).

  Recruiting University of Calgary · Calgary, Alberta · NCT04271878

• Comparing Propranolol and Ivabradine for treating POTS

  This study tests which medication, Propranolol or Ivabradine, works better to help people with Postural Tachycardia Syndrome feel better and manage their symptoms.

  Recruiting Phase 2 University of Calgary · Calgary, Alberta · NCT04186286

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.