Sleep and Teens’ Immune Response to a Meningococcal Vaccine
Official title: Sleep and Adolescent Vaccine Immunogenicity (SAVI) Pilot Study
Run by Children's Hospital Medical Center, Cincinnati · NCT07636525 · Data updated 2026-11-12
This study checks if 11- to 12-year-olds’ sleep habits affect how well their vaccine for meningococcal disease works.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 11 Years to 12 Years |
| Sex | All |
| Enrollment | 66 (estimated) |
| Sponsor | Children's Hospital Medical Center, Cincinnati Academic / other |
| Locations | 1 site (Cincinnati, Ohio) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | July 2027 |
| Study ends | July 2027 |
| Registry record updated | October 19, 2026 |
| Trial ID | NCT07636525 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy 11–12-year-olds who have not yet received the initial meningococcal vaccination and have no conditions or treatments causing immunosuppression.
✕Probably not a fit
Individuals with sleep disorders, significant sleep deprivation, or other factors that impair immune response may not experience clearer vaccine benefits in this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational pilot study monitors sleep patterns and vaccine response in healthy early teens receiving a meningococcal vaccine. Participants wear a sleep tracker and complete daily online diaries over five weeks, with two in-person visits for vaccination and a blood test. Sleep schedule consistency is encouraged, and results will be correlated with antibody responses to the vaccine. The study is conducted at Cincinnati Children’s Hospital Medical Center and led by the hospital, with no listed collaborators.
Why it matters
Potential benefit: If successful, the findings could inform recommendations on sleep optimization to potentially improve vaccine responses in adolescents.
How similar studies have gone: Some adult studies suggest sleep can influence immune responses, but pediatric data are limited and this approach is relatively novel in this age group.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy 11-12 years olds who have neither had initial meningococcal vaccination nor known exposure to meningococcal illness. Exclusion Criteria: * Condition or treatment resulting in immunosuppression * Prior severe vaccine reaction * Symptoms of clinical insomnia or organic sleep disorder * Known neurologic condition or intellectual/developmental disability * Use of a medication that impacts sleep * Average nightly sleep of 8-8.99 hours (between the two groups) * Daily intake of \>1 coffee or "energy drink" or \>2 caffeinated sodas.
Where it's running
-
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States Recruiting
Study contacts
- Principal investigator: Dean W Beebe, Ph.D. — Children's Hospital Medical Center, Cincinnati
- Study coordinator: Dean W Beebe, PhD
- Email: dean.beebe@cchmc.org
- Phone: 513-636-3489
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
RSV vaccine safety and immune response in lung transplant patients vs. healthy adults
This study tests how well the RSV vaccine works and how safe it is in people who have had a lung transplant compared with healthy adults.
-
OptiMAx: testing SQ-LNS to boost vaccination in rural Chad and Niger
This study tests whether giving small-batch SQ-LNS to young children helps increase routine immunizations in rural Chad and Niger.
-
Using fingerprint-linked digital records and reminders to help children finish their malaria and routine vaccines
This project will test whether a biometric-linked digital vaccination system plus voice-message reminders can help children in Ghana complete their malaria and routine vaccines.
-
Which vaccine messages grab attention in rural New England
This online test uses short social-media vaccine messages delivered by either experts or influencers to see which ones better catch attention and influence attitudes among adults living in rural New England.
-
Neutralizing power of blood and nasal antibodies
This project will test how strong blood and nasal antibodies remain over time in adults getting COVID-19 or monkeypox vaccines or antibody treatments.
-
VITAL: Try time-restricted eating to improve vaccine responses in older adults
This will test whether four weeks of time-restricted eating (an 8-hour daily eating window) helps people aged 60–85 mount stronger immune responses to seasonal influenza and COVID-19 vaccines.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.