Skin changes before and after CO₂ laser or Thermage treatment

Inclusion Criteria:

* 1\) Asian women, with age range from 30 to 59 years old;
* 2\) Be in general good health and good mental state;
* 3\) Presenting healthy skin as determined by Dermatologist;
* 4\) All Fitzpatrick skin types;
* 5\) All skin types on face (dry, normal, oily and combination) by subjects' self-perceived, with sensitive skin status confirmed and documented by a dermatologist;
* 6\) Facial skin exhibits specific characteristics (the mean baseline needs to be the same for 2 groups for all those parameters, before the pre-treatment phase T-2w) which require dermatological evaluation, detailed as follows: Crow's feet wrinkles: grade: 3≤ grade ≤5 (SKIN AGING ATLAS, page 40 to 41) Underneath eyes wrinkles: 3≤ grade ≤6 (SKIN AGING ATLAS, page 46 to 47) Ptosis of the lower part of the face: 1≤ grade ≤3 (SKIN AGING ATLAS, page 66 to 67) Lack of firmness: 3≤ grade ≤6 (9-point scale, 0 is the worst, 9 is the best) Pigmentary spots: 3≤ grade ≤5 (SKIN AGING ATLAS, page 79 to 81) (only for CO2 fractional laser Group)
* 7\) Willing to participate in one session of aesthetic procedure, either Fractional Ultrapulse CO₂-laser or Thermage procedure, after a 2-week wash-out period, followed by a 10-day self-recovery observation period.
* 8\) Aware and willing to accept that after a 10-day healing period, if the skin is not "ready" for the application of cosmetic products as determined by a dermatologist, they will be required to withdraw from the study;
* 9\) Have clean testing area (face): free of make-up on face, free of skin care products (lotions, sunscreens), make-up, perfumes, or other topical products on the visit day;
* 10\) Not currently be participating and will not participate in any other study involving the test area (face) for the duration of the study;
* 11\) Not have participated in any other study involving the test area (face) in the past 1 month;
* 12\) Be willing to read, understand and able to sign the Informed Consent Form \& Photo Release Form;
* 13\) Be willing to comply with all study protocol requirements.

Exclusion Criteria:

* 1\) Intending to get pregnant, be pregnant, be lactating, be within 6 months of delivery or be unwilling to take necessary precautions to avoid a pregnancy;
* 2\) Have any skin problems to impact clinical assessment, such as large areas of acne, scars, and open wounds, etc.;
* 3\) Having used antihistamine drugs in the past 1 week and one month after the treatment or immunosuppressants in the past 1 month;
* 4\) Take anti-allergic drug/injections in the past 1 month;
* 5\) Presently have allergies, allergic dermatitis or skin disease;
* 6\) Have sensitivity or even allergy to topical products, ingredients or fragranced products;
* 7\) Having a history of allergies, including but not limited to allergies to certain ingredients in cosmetics.
* 8\) Have history of suffering from skin diseases (such as psoriasis, eczema, psoriasis, skin cancer, etc.);
* 9\) Have used any anti-inflammatory treatment on the test area within 2 months prior to this study starting date;
* 10\) Has a chronic medical condition that may interfere with testing (e.g., asthma, insulin-dependent diabetes, lupus, rheumatoid arthritis or other immune/auto-immune diseases);
* 11\) Have received cosmetic medical procedures on the face (such as injectable anti-wrinkle products, cosmetic surgery, tattoo removal, home light facial procedures or home use medical devices, etc.) in the past 6 month; For Thermage group: priority screening for fillers, thread lifts, and metallic implants in the treatment area; For CO2 fractional laser Group: priority screening for laser treatments, peeling procedures, isotretinoin treatmentrecently and risk of herpes simplex virus (HSV) reactivation and post-inflammatory hyperpigmentation (PIH);
* 12\) Have excessive sun exposure or ultraviolet light in the past 1 month;
* 13\) Have applied Alpha hydroxyl acid, ortho-hydroxybenzoic acid, hydroquinone in the past 3 months; or used prescriptions (such as antibiotic, retinoids, alpha hydroxyl acid and steroid), oral contraceptives (such as Diane 35®，Jasmine®，Holgyeme®，Syndi 35®，Regulon®);
* 14\) Avoid providing emergency contact;
* 15\) Subjects that are not compliant to the selection criteria or not proper for participation as determined by Principal Investigator;
* 16\) An employee of the cosmetic companies or Shanghai China-Norm Quality Technical Service Co., Ltd.