Age-related facial skin structure in Chinese women measured with line-field confocal OCT

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, non-interventional, cross-sectional study will enroll about 100 Chinese female participants aged 20–70 to capture quantitative and qualitative skin properties. Data collection includes LC-OCT imaging, standardized photography, questionnaires, clinical assessments, and non-invasive biophysical measurements to build a histomorphometric database. The study focuses on Fitzpatrick skin phototypes II–III and excludes recent facial procedures, active tanning, or pregnancy to reduce confounding factors. Results will be used to characterize skin color, visible aging signs, and biomechanical properties and to support development and validation of ordinal photographic scales for aging research.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Chinese female, aged between 20 and 70 years (inclusive) at the time of signing consent.
2. Willing and able to provide written informed consent.
3. Fitzpatrick Skin Phototype II or III.
4. Willing to comply with all study procedures, including removal of facial makeup and avoidance of intensive skincare (e.g., retinoids, strong acids) on the test areas for 3 days prior to the visit as per instructions.

Exclusion Criteria:

1. Pregnant, planning pregnancy, or breastfeeding (as hormonal changes significantly affect skin properties).
2. Presence of temporary tanning, sunburn, or significant erythema on the face or measurement areas.
3. Presence of facial piercings, tattoos, too much fluff or significant scarring that would interfere with imaging or measurements in the areas of interest.
4. History of any aesthetic or surgical procedure on the face (e.g., laser therapy, chemical peels, injectable fillers, botulinum toxin, plastic surgery) within the past 12 months.
5. Current diagnosis or visible signs of a skin disease (e.g., psoriasis, eczema, active acne, rosacea) or a systemic disease known to affect the skin (e.g., diabetes, lupus) on the face or measurement areas.
6. Use of systemic medications known to affect skin physiology (e.g., oral retinoids, immunosuppressants, long-term corticosteroids) within the past 3 months, or for a cumulative duration of ≥6 months within the past 2 years.
7. Participation in another clinical study on the face or arms within the past 1 month.

Where it's running

• HKRI Centre One
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Yanwen Jiang
• Email: jiangyanwen@china-norm.com
• Phone: 13501700841

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.