12-week nutrient supplement for skin appearance and overall well-being

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, placebo-controlled trial enrolling 120 healthy Chinese adults with low daily fruit and vegetable intake. Participants are randomly assigned to take either a combination of vitamin C & green tea capsules plus multivitamin/mineral capsules or a matching placebo for 12 weeks. Primary outcomes are objective skin measures obtained by facial imaging (spots, redness, evenness) and probe measurements (elasticity, moisture, gloss); secondary outcomes include self-reported health status (quality of life, fatigue, digestive health), psychological resilience, and memory, along with exploration of a novel measurement method. Assessments occur at baseline and after the 12-week intervention to compare changes between groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Chinese adults of Asian descent aged 18 and above;
2. Daily fruit and vegetable intake \< 240g (calculated based on the fruit and vegetable section of the food frequency questionnaire);
3. S3 measurement index \< 30000;
4. Participants must possess basic Chinese reading comprehension and expression skills, and be able to independently complete questionnaire surveys;
5. Voluntary participation in the test and signing of the informed consent form;
6. Willingness to comply with all evaluation requirements.

Exclusion Criteria:

1. Presence of open facial skin lesions, clearly visible scars, acne marks, etc.;
2. Skin lesions, scars, or significant pigmentation on the hand measurement area;
3. Symptoms of skin disease on the face or hand measurement areas;
4. Having undergone medical aesthetic procedures within the last 6 months;
5. Participation in other clinical trials involving product use within the last 3 months;
6. Use of health supplements or nutritional supplements (e.g., vitamins, minerals) within the last 1 month;
7. Currently planning for pregnancy, pregnant, or lactating;
8. Presence of any disease under current treatment;
9. Any other health issues or chronic diseases that affect behavioral or cognitive abilities;
10. Other iatrogenic reasons identified by experts or professionals that may affect the evaluation results.

The S3 instrument refers to a Raman spectroscopy-based biophotonic scanner. The threshold for the S3 screening value is based on previously published literature, which indicated that participants with a daily fruit and vegetable intake of less than 240g had an average Raman spectroscopy biophotonic scanner score below 25,000. However, considering practical recruitment challenges, the inclusion criterion was set at \< 30,000. The S3 device measures the Skin Carotenoid Index, a non-invasive biomarker reflecting skin carotenoid levels.

Where it's running

• Shanghai China-norm Quality Technical Service Co., Ltd.
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Yanwen Jiang
• Email: jiangyanwen@china-norm.com
• Phone: 13501700841

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.