12-week nutrient supplement for skin appearance and overall well-being
The Impact of 12 Week Retention of Nutrients on Skin and the Perception of Physical Health Status
This study will test whether taking vitamin C & green tea plus a multivitamin/mineral supplement for 12 weeks helps improve skin appearance and perceived health in healthy Chinese adults who eat few fruits and vegetables.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | ChinaNorm Industry-sponsored |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT07383974 on ClinicalTrials.gov |
What this trial studies
This is a randomized, double-blind, placebo-controlled trial enrolling 120 healthy Chinese adults with low daily fruit and vegetable intake. Participants are randomly assigned to take either a combination of vitamin C & green tea capsules plus multivitamin/mineral capsules or a matching placebo for 12 weeks. Primary outcomes are objective skin measures obtained by facial imaging (spots, redness, evenness) and probe measurements (elasticity, moisture, gloss); secondary outcomes include self-reported health status (quality of life, fatigue, digestive health), psychological resilience, and memory, along with exploration of a novel measurement method. Assessments occur at baseline and after the 12-week intervention to compare changes between groups.
Who should consider this trial
Good fit: Ideal candidates are healthy Chinese adults (Asian descent) aged 18 or older who consume less than 240 g of fruits and vegetables per day, have an S3 index under 30000, can read Chinese to complete questionnaires, and meet skin-related eligibility criteria.
Not a fit: People with active facial or hand skin disease, recent medical aesthetic procedures, recent use of other clinical products or health supplements, or those who already consume adequate fruits and vegetables are less likely to benefit.
Why it matters
Potential benefit: If successful, the supplement combination could modestly improve skin appearance and how healthy people feel, especially for those with low fruit and vegetable intake.
How similar studies have performed: Previous small studies suggest antioxidants like vitamin C and green tea can modestly improve some skin measures, but results are mixed and combinations with multivitamins are not conclusively proven.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Chinese adults of Asian descent aged 18 and above; 2. Daily fruit and vegetable intake \< 240g (calculated based on the fruit and vegetable section of the food frequency questionnaire); 3. S3 measurement index \< 30000; 4. Participants must possess basic Chinese reading comprehension and expression skills, and be able to independently complete questionnaire surveys; 5. Voluntary participation in the test and signing of the informed consent form; 6. Willingness to comply with all evaluation requirements. Exclusion Criteria: 1. Presence of open facial skin lesions, clearly visible scars, acne marks, etc.; 2. Skin lesions, scars, or significant pigmentation on the hand measurement area; 3. Symptoms of skin disease on the face or hand measurement areas; 4. Having undergone medical aesthetic procedures within the last 6 months; 5. Participation in other clinical trials involving product use within the last 3 months; 6. Use of health supplements or nutritional supplements (e.g., vitamins, minerals) within the last 1 month; 7. Currently planning for pregnancy, pregnant, or lactating; 8. Presence of any disease under current treatment; 9. Any other health issues or chronic diseases that affect behavioral or cognitive abilities; 10. Other iatrogenic reasons identified by experts or professionals that may affect the evaluation results. The S3 instrument refers to a Raman spectroscopy-based biophotonic scanner. The threshold for the S3 screening value is based on previously published literature, which indicated that participants with a daily fruit and vegetable intake of less than 240g had an average Raman spectroscopy biophotonic scanner score below 25,000. However, considering practical recruitment challenges, the inclusion criterion was set at \< 30,000. The S3 device measures the Skin Carotenoid Index, a non-invasive biomarker reflecting skin carotenoid levels.
Where this trial is running
Shanghai, Shanghai Municipality
- Shanghai China-norm Quality Technical Service Co., Ltd. — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Study coordinator: Yanwen Jiang
- Email: jiangyanwen@china-norm.com
- Phone: 13501700841
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.