Single versus multiple in‑office bleaching applications and tooth sensitivity
Official title: The Effect of Single and Multiple Application of In-office Dental Bleaching on Tooth Sensitivity and Bleaching Efficacy: a Single-blind Randomized Controlled Trial
Run by King Abdullah University Hospital · NCT07173296 · Data updated 2026-11-12
This will test whether a single longer application versus multiple shorter applications of two common in‑office whitening gels changes how often or how much adults feel tooth sensitivity during whitening.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 35 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | King Abdullah University Hospital Academic / other |
| Locations | 1 site (Irbid) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | September 1, 2026 |
| Study ends | September 30, 2026 |
| Registry record updated | September 15, 2025 |
| Trial ID | NCT07173296 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with good general and oral health, at least eight upper front teeth with initial shade C2 or darker, no prior bleaching or recent desensitizing use, and ability to attend in‑person visits are ideal candidates.
✕Probably not a fit
People with active caries or periodontal disease, existing tooth sensitivity, restorations on the treated surfaces, prior bleaching, smokers, or pregnant/lactating women are unlikely to qualify or benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, single‑blind, split‑mouth trial at Jordan University of Science and Technology compares single versus multiple application protocols for two high‑concentration hydrogen peroxide gels (Pola Office Plus 37.5% HP and Opalescence Boost 40% HP). Eligible adults with at least eight maxillary anterior teeth and shade C2 or darker will receive different protocols on opposite hemiarches, with outcome evaluators blinded to allocation. The primary outcomes are the absolute risk and intensity of tooth sensitivity, and secondary outcomes include bleaching efficacy measured by shade change. Blocked randomization and a planned sample size (about 30 patients per group) are used to detect clinically meaningful differences.
Why it matters
Potential benefit: If successful, the results could identify an application protocol that reduces whitening‑related tooth sensitivity while maintaining bleaching effectiveness.
How similar studies have gone: Previous studies report high sensitivity rates with in‑office bleaching and some interventions can lessen symptoms, but direct comparisons of single versus multiple application protocols with these specific gels are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least eight maxillary anterior teeth present. * Age over 18 * The selected teeth have a mean shade of C2 or darker. * Good general and oral health. (no visible plaque or gingivitis) * No restorations or carious lesions on the buccal surfaces of the anterior teeth to be whitened * No history of tooth sensitivity * No use of a desensitizing agent or desensitizing toothpaste in the past six months * No use of pain killer for the last 48 hours Exclusion Criteria: * Active caries and/or periodontal diseases (gingivitis and recession) or wasting diseases * Smokers * Pregnant/lactating women. * Patients who have bleached their teeth previously. * No schedule availability
Where it's running
-
Jordan University of Science and Technology
Irbid, Jordan Recruiting
Study contacts
- Principal investigator: Ghada A Maghaireh — Jordan University of Science and Technology
- Study coordinator: Ghada A Maghaireh
- Email: gmaghair@just.edu.jo
- Phone: 0798809296
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.