See if ARNi therapy helps people with high blood pressure in the UAE

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will look at how well ARNi therapy, compared with antihypertensive monotherapy such as ACE inhibitors, ARBs, or calcium channel blockers, lowers blood pressure in adults with hypertension. It uses real-world clinical practice data to assess effectiveness after initiating ARNi or transitioning from monotherapy to ARNi. The study focuses on patients residing in the UAE and follows standard care without randomization or experimental interventions. Eligibility includes adults with diagnosed hypertension and elevated office blood pressure, with requirements around treatment transition and consent. Exclusion criteria omit patients with severely high blood pressure at baseline and certain other conditions as defined by protocol.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Adult male or female patients (≥18 years).
2. Patients with physician-diagnosed hypertension (as defined by international guidelines including the American Heart Association/American College of Cardiology \[AHA/ACC\] guidelines and/or the 2024 European Society of Cardiology \[ESC\] guidelines).
3. Patients with documented office blood pressure ≥130/80 mmHg prior to initiating treatment (ARNi or monotherapy) or transitioning from monotherapy to ARNi.
4. Patients who are either antihypertensive therapy naïve or currently receiving antihypertensive monotherapy (ACE inhibitor/ARB/CCB) with a physician-directed requirement to transition to ARNi.

   Note: Patients who transition from one monotherapy to another during the study are not eligible for inclusion.
5. Patients willing to provide written informed consent to participate in the study.

Exclusion criteria:

1. Patients with malignant or severe hypertension (systolic blood pressure \[SBP\] ≥180 mmHg, diastolic blood pressure \[DBP\] ≥110 mmHg) at baseline.
2. Patients with secondary causes of hypertension, as determined by the treating physician.
3. Patients with a history of, or at risk of developing, angioedema.
4. Patients with evidence of severe renal impairment (e.g., estimated glomerular filtration rate \[eGFR\] \<30 mL/min/1.73 m\^2).
5. Pregnant or lactating women.
6. Patients with serum potassium level ≥5.5 mmol/L at baseline.

Where it's running

• Novartis Investigative Site
  Abu Dhabi, United Arab Emirates Recruiting
• Novartis Investigative Site
  Dubai, United Arab Emirates Recruiting
• Novartis Investigative Site
  Fujairah, United Arab Emirates Recruiting
• Novartis Investigative Site
  Ras al-Khaimah, United Arab Emirates Recruiting

Study contacts

• Study coordinator: Novartis Pharmaceuticals
• Email: novartis.email@novartis.com
• Phone: +41613241111

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using low-dose aspirin after preeclampsia to improve recovery

  This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06281665

• IMB-guided health education to boost medication taking and blood pressure control in adults with hypertension

  This study tests a health-literacy program based on Information-Motivation-Behavioral Skills to help adults with hypertension who don’t take their medicines regularly to take them more consistently and better control their blood pressure.

  Recruiting at 8 sites Bahir Dar University · Ādēt and 7 other locations · NCT07894068

• Renal Nerve Stimulation to Help Blood Pressure in AF and HFpEF

  This study tests whether stimulating the kidneys with a catheter can safely lower blood pressure in adults with atrial fibrillation and HFpEF who also have hypertension.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT07893821

• Hypertension: Does Education Help Patients Manage Blood Pressure Better?

  This study tests whether structured patient education improves blood pressure control and self-management in adults with hypertension who speak Turkish.

  Recruiting Inonu University · Batman, Center · NCT07890090

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

• Long-term GW906 treatment for people with essential hypertension

  This trial tests whether long-term GW906 injections are safe and effective for adults with essential hypertension who completed an earlier GW906 study.

  Recruiting Shenzhen Salubris Pharmaceuticals Co., Ltd. · Shanghai, Shanghai Municipality · NCT07879755

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.