Screening for bronchopulmonary cancer in a structured network

Optimizing the Implementation of Bronchopulmonary Cancer Screening in the Ile de France Region (OPTI-DEPIST-MUT)

This study is testing a new way to screen for lung cancer using special scans in a network of health centers to see if it helps catch the disease early.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 500 (estimated)
• Ages: 50 Years to 74 Years
• Sex: All
• Sponsor: Institut Curie (Academic / other)
• Locations: 8 sites (Bobigny and 7 other locations)
• Trial ID: NCT06439901 on ClinicalTrials.gov

What this trial studies

This study evaluates the feasibility of conducting initial screenings for bronchopulmonary cancer using thoracic scanners within a dedicated network in the Île-de-France region. It involves defining eligibility criteria based on established guidelines, training health center physicians for referrals, and performing chest CT scans according to standardized recommendations. The study also includes centralized reading of CT images and referrals to multidisciplinary teams for suspected cases, as well as support for smoking cessation for eligible participants. The goal is to establish an effective screening process for early detection of bronchopulmonary cancer.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 50 to 74 who are current or recent smokers with a significant smoking history.

Not a fit: Patients with active cancer, recent cancer history, or symptoms suggestive of bronchopulmonary cancer will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved early detection and management of bronchopulmonary cancer, potentially saving lives.

How similar studies have performed: Other studies have shown success with similar screening approaches, particularly in high-risk populations, indicating potential for effective implementation.

Eligibility criteria

Inclusion Criteria:

* Participant aged 50 to 74.
* Resident in the Île-de-France region.
* Active smoker or quit smoker for 10 years or less:

  1. more than 10 cigarettes a day for more than 30 years,
  2. more than 15 cigarettes a day for more than 25 years.
* The participant has been informed and has signed the consent form.
* Social Security System affiliation.
* Willingness to participate in a smoking cessation program, if currently smoking.

Exclusion Criteria:

* Active cancer or a history of cancer in remission for less than 5 years (except basal cell carcinoma of th skin or epithelioma in situ of the uterine cervix).
* Presence of symptoms suggestive of bronchopulmonary cancer. Participants with these symptoms require immediate diagnostic investigations and are therefore not eligible for screening.
* Weight \>= 140 kg.
* Severe comorbidity contraindicating therapeutic options or invasive thoracic diagnostic investigations.
* Inability to climb two flights of stairs without stopping.
* A thoracic CTscan performed within the previous year.
* Persons deprived of liberty or under guardianship.
* Impossibility to undergo the medical monitoring of the trial for geographical, social or psychological reasons.

Where this trial is running

Bobigny and 7 other locations

• Centre CTPS Bobigny Bondy — Bobigny, France (Not_yet_recruiting)
• Centre Municipal de Santé Simone Veil — Issy-les-Moulineaux, France (Not_yet_recruiting)
• Centre Municipal de Santé Jacqueline Akoun-Cornet — Malakoff, France (Not_yet_recruiting)
• Centre Municipal de Santé Maurice Ténine — Malakoff, France (Not_yet_recruiting)
• Centre de Santé Square de la Mutualité — Paris, France (Recruiting)
• Institut Curie — Paris, France (Not_yet_recruiting)
• Institut Mutualiste Montsouris — Paris, France (Not_yet_recruiting)
• Centre de Santé MGEN — Paris, France (Not_yet_recruiting)

Study contacts

• Study coordinator: Catherine DANIEL, MD

Conditions Bronchopulmonary Disease; Diagnoses Disease; bronchopulmonary cancer; screening; primary prevention