Screening for bronchopulmonary cancer in a structured network
Official title: Optimizing the Implementation of Bronchopulmonary Cancer Screening in the Ile de France Region (OPTI-DEPIST-MUT)
Run by Institut Curie · NCT06439901 · Data updated 2026-11-12
This study is testing a new way to screen for lung cancer using special scans in a network of health centers to see if it helps catch the disease early.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years to 74 Years |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Institut Curie Academic / other |
| Locations | 9 sites (Bobigny and 8 other locations) |
| Status | Recruiting |
| Started | January 27, 2025 |
| Main results expected | February 5, 2033 |
| Study ends | February 5, 2034 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT06439901 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 50 to 74 who are current or recent smokers with a significant smoking history.
✕Probably not a fit
Patients with active cancer, recent cancer history, or symptoms suggestive of bronchopulmonary cancer will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the feasibility of conducting initial screenings for bronchopulmonary cancer using thoracic scanners within a dedicated network in the Île-de-France region. It involves defining eligibility criteria based on established guidelines, training health center physicians for referrals, and performing chest CT scans according to standardized recommendations. The study also includes centralized reading of CT images and referrals to multidisciplinary teams for suspected cases, as well as support for smoking cessation for eligible participants. The goal is to establish an effective screening process for early detection of bronchopulmonary cancer.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and management of bronchopulmonary cancer, potentially saving lives.
How similar studies have gone: Other studies have shown success with similar screening approaches, particularly in high-risk populations, indicating potential for effective implementation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant aged 50 to 74. * Resident in the Île-de-France region. * Active smoker or quit smoker for 10 years or less: 1. more than 10 cigarettes a day for more than 30 years, 2. more than 15 cigarettes a day for more than 25 years. * The participant has been informed and has signed the consent form. * Social Security System affiliation. * Willingness to participate in a smoking cessation program, if currently smoking. Exclusion Criteria: * Active cancer or a history of cancer in remission for less than 5 years (except basal cell carcinoma of th skin or epithelioma in situ of the uterine cervix). * Presence of symptoms suggestive of bronchopulmonary cancer. Participants with these symptoms require immediate diagnostic investigations and are therefore not eligible for screening. * Weight \>= 140 kg. * Severe comorbidity contraindicating therapeutic options or invasive thoracic diagnostic investigations. * Inability to climb two flights of stairs without stopping. * A thoracic CTscan performed within the previous year. * Persons deprived of liberty or under guardianship. * Impossibility to undergo the medical monitoring of the trial for geographical, social or psychological reasons.
Where it's running
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Centre Municipal de Santé Simone Veil
Issy-les-Moulineaux, France Recruiting -
Centre Municipal de Santé Maurice Ténine
Malakoff, France Recruiting -
Centre de Santé Square de la Mutualité
Paris, France Recruiting -
Centre de Santé MGEN
Paris, France Recruiting -
Centre CTPS Bobigny Bondy
Bobigny, France Not yet recruiting -
Centre Municipal de Santé de Gentilly
Gentilly, France Not yet recruiting
Show 3 more locations
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Centre Municipal de Santé Jacqueline Akoun-Cornet
Malakoff, France Not yet recruiting -
Institut Curie
Paris, France Not yet recruiting -
Institut Mutualiste Montsouris
Paris, France Not yet recruiting
Study contacts
- Study coordinator: Catherine DANIEL, MD
- Email: catherine.daniel@curie.fr
- Phone: +33 1 44 32 40 00
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.