Heart heartbeats: using PEG to separate macrotroponin from real troponin elevations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In people with suspected heart events and in trained athletes, troponin can stay elevated for reasons other than acute disease. The study uses polyethylene glycol precipitation (PEG) to see if it can unmask macrotroponin and clarify troponin results. It compares ACS patients undergoing invasive coronary angiography with healthy marathon runners who have rested or just finished a race. Baseline labs and imaging are collected, and PEG and echocardiography are repeated around key time points. The primary outcome is the ability of PEG to reveal macrotroponin and differentiate it from real troponin elevation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age above 18 years
* Group with acute coronary syndrome (ACS): Diagnosis of ACS (ST-segment elevation or non-ST-segment elevation myocardial infarction according to the European Society of Cardiology Guidelines 2023 with at least one measurement of high sensitive troponin I or T above the 99th percentile of reference).
* Marathon runners: Participation in a marathon following cardiological pre-participation screening and medical clearance for competition. No clinical signs of cardiovascular or structural heart disease

Exclusion Criteria:

* Patients with acute coronary syndrome: Known macrotroponin, terminal renal disease (glomerular filtration rate below 10ml per minute), diagnosis of cancer, pregnancy
* Marathon runners: Coronary artery disease, structural heart disease, diagnosis of cancer, pregnancy

Where it's running

• Technical University Munich
  Munich, Bavaria, Germany Recruiting

Study contacts

• Principal investigator: Simon Wernhart, MD, PhD — TUM - Technische Universität München
• Study coordinator: Simon Wernhart, MD, PhD
• Email: simon.wernhart@gmx.de
• Phone: +491751830099

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.