Routine antiemetic prophylaxis for non-fasted parturients having cesarean delivery with spinal anesthesia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, double-blind study, non-fasted parturients undergoing emergency cesarean delivery under spinal anesthesia are assigned to receive either a 5-HT3 receptor antagonist or a dopamine receptor antagonist as routine antiemetic prophylaxis to prevent intraoperative nausea and vomiting. Eligible participants are ASA I-II pregnant women aged 18 or older with a singleton pregnancy. Participants and clinicians are blinded to treatment allocation, and outcomes focus on the incidence of intraoperative nausea and vomiting. The study aims to optimize antiemetic strategies to improve maternal comfort and perioperative safety during emergency cesarean deliveries.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pregnant women scheduled for emergency cesarean delivery under spinal anesthesia
* Non-fasted (full-stomach) parturients
* American Society of Anesthesiologists (ASA) physical status I-II
* Age ≥ 18 years
* Singleton pregnancy
* Ability to provide written informed consent

Exclusion Criteria:

* ASA physical status III or higher
* Refusal to participate
* Elective cesarean delivery (non-emergency cases)
* Preoperative antiemetic use within 24 hours before surgery
* Known allergy or contraindication to study drugs (ondansetron or metoclopramide)
* Pre-existing gastrointestinal disorders (e.g., severe GERD, gastroparesis, bowel obstruction)
* Psychiatric illness or current use of psychotropic medications
* Preoperative anemia (as defined by institutional threshold, e.g., Hb \< 10 g/dL)
* Intraoperative conversion to general anesthesia
* Massive intraoperative hemorrhage (\>1000-1500 mL or requiring transfusion, depending on your protocol definition)
* Intraoperative administration of additional sedative or antiemetic agents outside study protocol
* Multiple gestation pregnancies

Where it's running

• Sanliurfa Education and Research Hospital
  Sanliurfa, Eyyübiye, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Tolga Karaçay
• Email: tkaracay35@gmail.com
• Phone: +905458718351

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.