Understanding nausea and vomiting after elective C-sections under spinal anesthesia
Official title: Incidence and Risk Factors of Postoperative Nausea and Vomiting (PONV) During Elective C-Section Under Spinal Anesthesia With Multimodal Antiemetic Prophylaxis
Run by University of Liege · NCT06927830 · Data updated 2026-11-12
This study looks at how often women feel nauseous or vomit after having a planned C-section with spinal anesthesia and what might cause it.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 400 (estimated) |
| Sponsor | University of Liege Academic / other |
| Locations | 2 sites (Chenée and 1 other locations) |
| Status | Recruiting |
| Started | March 19, 2025 |
| Main results expected | March 2026 |
| Study ends | April 2026 |
| Registry record updated | April 15, 2025 |
| Trial ID | NCT06927830 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients requiring elective cesarean sections at a gestational age greater than 37 weeks with a single fetus.
✕Probably not a fit
Patients with contraindications to spinal anesthesia or those who have experienced nausea and vomiting in the 24 hours prior to the procedure may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the frequency and risk factors associated with postoperative nausea and vomiting (PONV) in patients undergoing elective cesarean sections with spinal anesthesia. Participants will be monitored for nausea and vomiting in the recovery room and during follow-up visits within the first 24 hours post-surgery. The study will utilize a standard management protocol that includes the administration of intrathecal morphine and multimodal antiemetic prophylaxis. Data collected will help identify the incidence of PONV and the factors that may contribute to its occurrence.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for preventing nausea and vomiting in patients undergoing cesarean sections.
How similar studies have gone: Previous studies have shown varying success in managing postoperative nausea and vomiting in similar surgical contexts, indicating that this area of research is both relevant and necessary.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Any patient requiring elective caesarean section under spinal anesthesia, at a gestational age \>37 weeks of amenorrhea in the context of a single-fetal pregnancy. Exclusion Criteria: Failure to understand the French language; Contraindication to locoregional anesthesia; Nausea and/or vomiting in the 24 hours preceding the procedure; Type 1 or type 2 insulin-requiring non-gestational diabetes; Allergy or contraindication to one of the products used in the usual management protocol; Severe preeclampsia; Height \<150 cm
Where it's running
-
CHU de Liège - site de Notre-Dame des Bruyères
Chenée, Belgium Recruiting -
Hôpital de la Citadelle - site Citadelle
Liège, Belgium Not yet recruiting
Study contacts
- Study coordinator: Thibault Michot, M.D.
- Email: tmichot@chuliege.be
- Phone: +32 4 3234141
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.