Rhombod Intercostal Sub-Serratus Plane Block vs External Oblique Intercostal Block for Open Nephrectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients undergoing open nephrectomy are randomized to receive either a rhomboid intercostal sub-serratus plane block or an external oblique intercostal block for perioperative analgesia, with intravenous morphine as rescue. The trial compares the time to first request for analgesia between the two blocks. The RISS approach targets nerves from T4 to T9 and has been used in thoracic and upper abdominal surgeries; this study evaluates its effectiveness in open nephrectomy. Safety and analgesic duration will be monitored as secondary considerations. The design focuses on practical perioperative pain outcomes and could inform best regional anesthesia practices for this surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Both sexes.
* American Society of Anesthesiologists (ASA) physical status II, III.
* Body mass index (BMI): \> 20 kg/ m2 and \< 35 kg/ m2.
* Patients undergoing open nephrectomy.

Exclusion Criteria:

* Patient refusal.
* BMI \<20 kg/m2 and \>35 kg/m2
* Known sensitivity or contraindication to drug used in the study (local anesthetics, opioids).
* History of psychiatric and cognitive disorders or chronic pain.
* Contraindication to regional anesthesia e.g pre- existing peripheral neuropathies.
* Severe respiratory or cardiac disorders.
* Advanced liver or kidney disease.
* Pregnancy.
* Physical status ASA IV.
* Coagulopathy with INR ≥ 1.6: hereditary (e.g. hemophilia, fibrinogen abnormalities \& deficiency of factor II) - acquired (e.g. impaired liver functions with prothrombin concentration less than 60 %, vitamin K deficiency \& therapeutic anticoagulants drugs).

Where it's running

• Cairo University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Amr R Seif, MD
• Email: amroseifo40404@gmail.com
• Phone: 00201066588692

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Modified external oblique intercostal plane block vs erector spinae plane block for open nephrectomy

  This trial tests whether the EOIPB or ESPB provides better pain relief after open nephrectomy in adults.

  Recruiting Namik Kemal University · Tekirdağ, Tekirdağ · NCT07726550

• Comparing two ultrasound-guided nerve blocks for pain after open kidney removal

  We will test whether a serratus intercostal plane block or an erector spinae plane block provides better pain relief for adults having open nephrectomy.

  Recruiting Fayoum University Hospital · Al Fayyum · NCT07556536

• Comparing two methods of pain control after kidney surgery in cancer patients

  This study is testing two different ways to control pain after kidney surgery in cancer patients to see which method works better.

  Recruiting National Cancer Institute, Egypt · Cairo · NCT06889987

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.