Resistance exercise with blood flow restriction for heart failure with reduced ejection fraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study evaluates a resistance training program performed with vascular occlusion to see if it improves left ventricular function and muscle strength in patients with heart failure and reduced ejection fraction. Participants perform resistance exercises with a device that restricts blood flow during sessions. The approach targets those who cannot sustain high-intensity training by using lower intensities while aiming to achieve beneficial adaptations. Outcomes focus on cardiac function and peripheral conditioning measured through imaging and functional tests.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* LVEF ≤ 50%
* Patients with an indication for cardiovascular rehabilitation in the first stay or not (according to national recommendations, as soon as possible after an exacerbation or at any time in a patient with chronic heart failure) (Bigot et al., 2024)
* No medical contraindication to physical activity
* Patient has given free and informed consent and signed the consent form
* Patient affiliated with or benefiting from a health insurance scheme

Exclusion Criteria:

* Patient participating in another Category I interventional study, or having participated in another interventional study in the last month
* Patient in an exclusion period determined by a previous study
* Patient under court protection, guardianship or curatorship
* Unable to provide informed consent, or patient refuses to sign consent form
* Pregnant, parturient or breast-feeding patient
* Moderate to severe peripheral arterial disease. Arterial Doppler scan for arterial stenosis, with measurement of femoral and distal flows.
* Active or recent deep vein thrombosis. Check with venous Doppler ultrasound, looking for venous compressibility at the roots of the thighs, and 4-point venous ultrasound.
* Medication known to alter the effects of ischemic conditioning (cyclosporine, glibenclamide).
* Uncontrolled arterial hypertension
* Severe valvular disease

Where it's running

• Nîmes University Hospital
  Nîmes, Gard, France Recruiting

Study contacts

• Principal investigator: Alice GAUTHIER, Dr. — Nîmes University Hospital
• Study coordinator: Clarisse BELVISI
• Email: clarisse.belvisi@chu-nimes.fr
• Phone: +33466683459

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.