Remimazolam vs propofol for stable blood pressure during thoracic/abdominal endovascular aortic repair

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, single-blind study compares two IV anesthetics—remimazolam besylate and propofol—in adults undergoing thoracic or abdominal endovascular aortic repair. The trial looks at intraoperative hemodynamic stability by measuring vasopressor needs during surgery. The goal is to determine which anesthetic produces fewer blood pressure fluctuations and less vasopressor support in high-risk patients. Findings could guide anesthetic choice to improve organ perfusion during these procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Adults aged 20 years or older scheduled for thoracic or abdominal endovascular aortic repair (TEVAR/EVAR) under general anesthesia for thoracic or abdominal aortic aneurysm

Exclusion Criteria:

* Known or suspected allergy or hypersensitivity to the study drugs
* ASA physical status class IV or higher
* Body mass index (BMI) ≥ 30 kg/m\^2
* Chronic use of opioids or benzodiazepines
* History of alcohol or drug abuse
* Preoperative cognitive impairment
* Severe left ventricular dysfunction (left ventricular ejection fraction \< 40%)
* Severe hepatic dysfunction (Child-Pugh class C)
* Severe hypoalbuminemia (\< 2.0 g/dL)
* Acute or chronic renal failure requiring dialysis
* Pregnancy or breastfeeding
* Emergency procedure

Where it's running

• Seoul National University Hospital
  Seoul, South Korea Recruiting

Study contacts

• Study coordinator: Youn Joung Cho, MD, PhD
• Email: mingming7@gmail.com
• Phone: 82-2-2072-2467

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.