Keep blood pressure at 85 or more during surgery to prevent delirium in older adults with hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized trial compares two intraoperative blood pressure strategies in adults aged 65 and older with arterial hypertension and at risk for delirium. The intervention aims to maintain MAP at 85 mmHg or higher, while the control follows routine care with MAP at 65 mmHg or higher. Outcomes include the incidence of delirium within the first three postoperative days, as well as delirium duration and other postoperative complications. Eligible participants are adults ≥65 scheduled for elective non-cardiac surgery under general anesthesia lasting at least 120 minutes and at high risk for delirium. Exclusion criteria include certain surgeries (e.g., intracranial, solid organ transplant), sepsis, or recent surgery within 30 days.

Why it matters

Who can join: the full rules

Inclusion Criteria:

To be eligible for trial inclusion, patients must:

* 1\) be able to provide informed consent, AND
* 2\) be ≥65 years old, AND
* 3\) be scheduled for elective non-cardiac surgery with general anesthesia that is expected to last ≥120 minutes, AND
* 4\) have chronic arterial hypertension requiring antihypertensive medication OR have a systolic arterial pressure ≥140 mmHg or diastolic arterial pressure ≥90 mmHg on a measurement performed within the previous year, AND
* 5\) be at high risk for postoperative delirium because: American Society of Anesthesiologists physical status class III or IV OR Charlson Comorbidity Index ≥3 points (please see Appendix 1) OR frailty (documented in medical records or clinical diagnosis)

Exclusion Criteria:

Patients that meet one or more of the following exclusion criteria cannot participate in the trial:

* solid organ transplant surgery
* intracranial surgery
* surgery in sitting position
* sepsis
* surgery in the previous 30 days
* previous participation in ASPIRE-85

Where it's running

• • Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg
  Hamburg, Germany Recruiting

Study contacts

• Study coordinator: Karim Kouz, MD
• Email: k.kouz@uke.de
• Phone: +4940741052415

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.