FAME: A Italian test to recognize famous faces and name them

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The I-FACE project develops and validates a comprehensive neuropsychological battery to assess famous-face recognition in individuals with neurodegenerative diseases and stroke. It covers three components—familiarity, semantic knowledge, and naming—and includes four tasks to measure these abilities. A pilot study will refine items and ensure internal consistency, followed by collecting Italian normative data by age, sex, and education, and establishing cut-off scores. The battery will then be administered to people with frontotemporal dementia, Alzheimer's disease, and stroke to evaluate reliability and validity and its ability to distinguish impaired from unimpaired recognition. The study uses neuropsychological assessment as the primary intervention.

Why it matters

Who can join: the full rules

1. Healthy Controls (HC)

   Inclusion Criteria:

   Age 40-85 years. No chronic medical, neurological, or psychiatric conditions, or major depressive episode detected during screening.

   No history of schizophrenia or bipolar disorder in the 5 years prior to screening.

   Mini-Mental State Examination (MMSE) score ≥ 26.

   Exclusion Criteria:

   Uncorrected vision or hearing impairment.
2. Frontotemporal Dementia (FTD) Patients

   Inclusion Criteria:

   Diagnosis of probable FTD according to established clinical criteria. Age 40-85 years. Ability to provide informed consent.

   Exclusion Criteria:

   History of neurological diseases other than FTD (e.g., stroke, brain tumor, multiple sclerosis, traumatic brain injury).

   Uncorrected vision or hearing impairment. History of serious psychiatric diseases, developmental disorders (e.g., autism spectrum), or intellectual disability.

   Dementia severity (CDR) \> 1.
3. Alzheimer's Disease (AD) Patients

   Inclusion Criteria:

   Diagnosis of probable AD according to established clinical criteria. Age 40-85 years. Ability to provide informed consent.

   Exclusion Criteria:

   History of neurological diseases other than AD (e.g., stroke, brain tumor, multiple sclerosis, traumatic brain injury).

   Uncorrected vision or hearing impairment. History of serious psychiatric diseases, developmental disorders, or intellectual disability.

   Dementia severity (CDR) \> 1.
4. Post-Stroke Patients

Inclusion Criteria:

Subacute phase: 1 week to 3 months post-event. Ischemic or hemorrhagic stroke confirmed by neuroimaging and/or clinical judgment.

Exclusion Criteria:

History of previous stroke or multifocal stroke documented by imaging. Brainstem or cerebellar stroke. History of traumatic brain injury (TBI), seizures, brain tumors, neurodegenerative diseases, or psychiatric disorders.

Where it's running

• ICS Maugeri Sciacca
  Sciacca, Ag, Italy Recruiting
• IRCCS Maugeri Lumezzane
  Lumezzane, Bs, Italy Recruiting
• ICS Maugeri Mistretta
  Mistretta, Me, Italy Recruiting
• IRCCS Maugeri Montescano
  Montescano, Pv, Italy Recruiting
• Istituti Clinici Scientifici Maugeri IRCCS Bari
  Bari, Italy Recruiting
• Istituti Clinici Scientifici Maugeri IRCCS Milano
  Milan, Italy Recruiting

Study contacts

• Principal investigator: Petronilla Battista, PhD — Istituti Clinici Scientifici Maugeri IRCCS
• Study coordinator: Petronilla Battista, PhD
• Email: petronilla.battista@icsmaugeri.it
• Phone: +39 0807814331

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.