Oral OT and AVP Effects on Attention to Emotional Faces in Healthy Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In a randomized, double-blind design, healthy adults receive oxytocin, vasopressin, or placebo through an oromucosal administration, then complete behavioral tasks and undergo fMRI to study attention to emotional faces and related brain activity. The study also collects baseline and post-treatment mood and personality measures to control for individual differences. Participants have a resting period after administration before imaging, with blood samples taken prior to scanning. The protocol compares top-down and bottom-up attention patterns and neural responses across the three groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy subjects without past or current psychiatric or neurological disorders
* Normal or corrected-to-normal vision
* Eligible for MRI scanning and willing to undergo blood sampling and study treatment administration
* For naturally cycling female participants, willingness and ability to complete the experimental session within the predefined menstrual-cycle phase, determined using menstrual history and urinary luteinizing hormone (LH) testing
* Willing to comply with study requirements regarding alcohol, caffeine, nicotine, medication use, and other pre-session restrictions

Exclusion Criteria:

* History of head injury or epilepsy or seizure disorders
* Current or past major psychiatric, neurological, or serious medical illness that may affect participant safety or study outcomes
* Current use of psychoactive medications, hormonal medications, or other medications that may substantially affect central nervous system or neuroendocrine function
* Regular smoking or inability to comply with the required nicotine abstinence period before testing
* Face recognition impairment or other visual-perceptual impairment that could interfere with performance of the emotional face tasks

Where it's running

• University of Electronic Science and Technology of China
  Chengdu, Sichuang, China Recruiting

Study contacts

• Study coordinator: Dr.
• Email: yaoshuxia@uestc.edu.cn
• Phone: 8618111297596

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.