Reducing slow-flow and no-reflow during STEMI with a high-dose intracoronary adenosine protocol

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study explores a prophylactic protocol of 200 micrograms of intracoronary adenosine given before each balloon or stent inflation during primary PCI in STEMI patients. The goal is to see if the adenosine protocol reduces slow-flow or no-reflow and improves post-procedure blood flow by TIMI and myocardial blush grading. Outcomes include incidence of SNR, coronary perfusion, and safety in the setting of PPCI. Participants are adults with STEMI undergoing primary PCI, with exclusion criteria designed to minimize risk in those with cardiogenic shock, hypotension, bradycardia, allergy to adenosine, severe asthma/COPD, pregnancy, SCAD, MINOCA, or difficult-to-cross lesions. The study compares the adenosine protocol to standard PPCI care without prophylactic adenosine.

Why it matters

Who can join: the full rules

Inclusion Criteria;

* 18 years and older of either gender
* Diagnosis of STEMI
* Undergoing primary PCI

Exclusion Criteria:

* Cardiogenic shock
* Severe hypotension (SBP \<90 mmHg)
* Bradycardia with HR \< 50 bpm without pacemaker
* Known hypersensitivity to adenosine
* Severe asthma or COPD with bronchospasm
* Pregnancy
* Spontaneous coronary artery dissection (SCAD)
* Myocardial Infarction in non - obstructive coronaries (MINOCA)
* Lesions unable to be crossed with coronary wire

Where it's running

• Punjab institute of cardiology Lahore
  Lahore, Punjab Province, Pakistan Recruiting
• Dow University of Health Sciences,Karachi
  Karachi, Sindh, Pakistan Recruiting

Study contacts

• Principal investigator: Muzaffar Ali Zahidi, MBBS,FCPS Med,FCPS Cardiology — Punjab Institute of Cardiology Lahore
• Study coordinator: Muzaffar Ali Zahidi, MBBS,FCPS Med,FCPS Cardiology
• Email: muzcardio@gmail.com
• Phone: +923004358267

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.