Investigating microplastics in patients with heart attacks

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the presence and impact of microplastics and nanoplastics (MNPs) in patients experiencing ST-elevation myocardial infarction (STEMI) who are undergoing urgent coronary intervention. It will assess the burden of MNPs in coronary thrombi and their association with cardiac damage, plaque vulnerability, and cardiovascular events. The study will utilize advanced imaging techniques like optical coherence tomography and cardiac magnetic resonance to evaluate the relationship between MNPs and cardiovascular health over a one-year follow-up period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All the following inclusion criteria should be fulfilled:

1. Age \> 18 years old;
2. STEMI undergoing urgent invasive coronary angiography;
3. Acute thrombotic coronary occlusion/sub-occlusion (TIMI 0/1);
4. Clinical indication to thromboaspiration;
5. Able to give informed consent.

Exclusion Criteria:

1. Contraindications to percutaneous coronary intervention;
2. Hemodynamic instability or cardiogenic shock;
3. End-stage chronic kidney disease;
4. Life expectancy \< 1 year due to non-cardiac pathology.

Where it's running

• Sant'Andrea University Hospital
  Roma, Rome, Italy Recruiting
• Azienda Ospedaliera Integrata Verona, Italy
  Verona, Italy Recruiting
• Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli
  Caserta, Italy Active not recruiting
• Division of Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", Caserta, Italy.
  Caserta, Italy Not yet recruiting
• Cardiovascular Department, A.O.U. Policlinico "G. Rodolico - San Marco", University of Catania, Catania, Italy.
  Catania, Italy Not yet recruiting
• Azienda Ospedaliero Universitaria di Ferrara, Cona, Italy
  Ferrara, Italy Not yet recruiting

Study contacts

• Study coordinator: Emanuele Barbato, MD, PhD
• Email: emanuele.barbato@uniroma1.it
• Phone: +39 0633776115

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Microplastics and nanoplastics in people with chronic coronary syndromes

  This study will test whether tiny plastic particles (micro- and nanoplastics) can be detected in the coronary blood of adults with suspected or known chronic coronary syndromes who are having coronary CT and invasive angiography.

  Recruiting at 2 sites Azienda Ospedaliera "Sant'Andrea" · Caserta and 5 other locations · NCT07291609

• Microplastics in the liver of people with cirrhosis and portal hypertension

  This study tests whether microplastics and nanoparticles accumulate in the livers of adults with cirrhosis and portal hypertension who are undergoing surgery or transplant, to understand where they go and what form they take.

  Recruiting at 2 sites Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh, Chandigarh and 1 other locations · NCT07280390

• Reducing slow-flow and no-reflow during STEMI with a high-dose intracoronary adenosine protocol

  In STEMI patients undergoing primary PCI, this trial tests whether giving a high-dose intracoronary adenosine before balloon or stent inflation can prevent slow-flow or no-reflow.

  Recruiting at 2 sites Punjab Institute of Cardology · Lahore, Punjab Province and 1 other locations · NCT07898696

• Drug-coated balloons vs drug-eluting stents for immediate slow-flow/no-reflow in STEMI with high thrombus

  This study tests whether using a drug-coated balloon instead of a drug-eluting stent during PCI helps reduce immediate slow-flow or no-reflow in STEMI patients with high thrombus burden.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT07806370

• CHIP in STEMI: Does clonal hematopoiesis influence infarct severity

  This study tests whether clonal hematopoiesis (CHIP) affects infarct size and microvascular injury in people having a heart attack treated with PCI.

  Recruiting Medical University Innsbruck · Innsbruck, Tyrol · NCT07615023

• Digitally supported personalized nutrition to improve heart pumping after ST‑elevation heart attack

  This program will test whether a three-month personalized diet plan with digital support can improve heart pumping (left ventricular ejection fraction) in adults who recently had a STEMI.

  Recruiting Saglik Bilimleri Universitesi · Samsun, Atakum · NCT07427199

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.