CHIP in STEMI: Does clonal hematopoiesis influence infarct severity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, observational cohort study at a single center aiming to enroll 350 adults aged 18-75 with STEMI treated by primary PCI. Participants will undergo genetic testing for CHIP mutations and a cardiac MRI about 5 days after PCI to measure microvascular obstruction, intramyocardial hemorrhage, and infarct size, along with ventricular function. The study explores whether CHIP-associated inflammation contributes to worse ischemia–reperfusion injury beyond standard care. No experimental intervention is given; all care remains standard. Data will be used to understand potential links between CHIP and adverse cardiac remodeling after STEMI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of first acute ST-elevation myocardial infarction according to current European Society of Cardiology guidelines
* Symptoms consistent with ST-elevation myocardial infarction lasting more than 30 minutes and less than 12 hours before primary percutaneous coronary intervention
* Treatment with primary percutaneous coronary intervention
* Age 18 to 75 years
* Written informed consent

Exclusion Criteria:

* Prior myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
* Persistent hemodynamic instability, Killip class greater than 2 including cardiogenic shock, or resuscitated cardiac arrest not allowing cardiac magnetic resonance imaging
* Known active or prior malignancy, including hematologic malignancies or myelodysplastic syndromes
* Prior oncologic treatment with chemotherapy, radiotherapy, or radioisotopes
* Abnormal baseline complete blood count with clinically significant cytopenia, defined as leukocytes less than 3.0 x 10\^9/L, platelets less than 100 x 10\^9/L, or hemoglobin less than 10 g/dL
* Chronic viral infection associated with systemic inflammation
* Active autoimmune disease or chronic systemic inflammatory disorder
* Chronic kidney disease with creatinine clearance less than 30 mL/min/1.73 m2
* Contraindication to cardiac magnetic resonance imaging
* Pre-ST-elevation myocardial infarction life expectancy of less than 1 year
* Participation in an interventional trial
* Limited possibility to attend follow-up examinations, for example residence abroad
* Pregnancy

Where it's running

• Medical University of Innsbruck
  Innsbruck, Tyrol, Austria Recruiting

Study contacts

• Study coordinator: Ivan Lechner, MD, PhD
• Email: ivan.lechner@tirol-kliniken.at
• Phone: +43 512 504 83772

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.