Pulse Wave Transit Time after Infraclavicular Block
Official title: Time-Dependent Changes in Pulse Wave Transit Time Following Infraclavicular Block: A Non-Invasive Assessment of Sympathetic Blockade
Run by Sakarya University · NCT07669688 · Data updated 2026-11-12
This study tests whether PWTT, a noninvasive heart-to-peripheral pulse timing measure, changes after an ultrasound-guided infraclavicular brachial plexus block in adults undergoing upper extremity surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | Sakarya University Academic / other |
| Locations | 2 sites (Sakarya and 1 other locations) |
| Status | Recruiting |
| Started | August 1, 2026 |
| Main results expected | October 26, 2026 |
| Study ends | November 15, 2026 |
| Registry record updated | October 30, 2026 |
| Trial ID | NCT07669688 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 undergoing elective upper extremity hand surgery with ASA I status and no coagulopathy.
✕Probably not a fit
Patients with contraindications to regional anesthesia, significant cardiac disease, BMI ≥ 30, or chronic opioid use may not experience benefit from PWTT as a marker.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study will monitor PWTT and other noninvasive hemodynamic indicators before and after ultrasound-guided infraclavicular brachial plexus block in adults undergoing elective upper-extremity surgery. Measurements will be collected at predefined time points to assess time-dependent changes related to sympathetic blockade. Secondary outcomes include perfusion index, skin temperature, heart rate, blood pressure, respiratory rate, and oxygen saturation. The study aims to determine if PWTT can serve as an objective marker of sympathetic blockade in regional anesthesia, particularly in patients who may be sedated or unable to participate in traditional sensory/motor assessments.
Why it matters
Potential benefit: If PWTT proves to track sympathetic blockade reliably, clinicians could have a simple, noninvasive marker to confirm block effectiveness across a wider range of patients.
How similar studies have gone: Prior studies have suggested PWTT and other noninvasive measures may reflect autonomic blockade, but temporal PWTT dynamics after infraclavicular block are not well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing elective upper extremity hand surgery * 18 - 65 years * ASA I * No coagulopathy, thrombocytopenia, coagulation disorders * Patients who provide informed consent to participate in the study Exclusion Criteria: * History of drug allergy relevant to study procedures or local anesthetics * Body mass index (BMI) ≥ 30 kg/m² * Body weight \< 40 kg * Age \< 18 years or \> 65 years * History of significant cardiac disease (e.g., arrhythmia, conduction abnormalities) * Coagulopathy (INR \> 1.5 or platelet count \< 100,000/mm³) * Pregnancy or lactation * Infection at the site of peripheral nerve block * ASA II-IV * Failed block or motor block duration exceeding 30 minutes * Patients reporting pain (NRS ≥ 3), due to potential influence on sympathetic activity * Chronic opioid use
Where it's running
-
Sakarya University-Anesthesiology and Reanimation Department
Sakarya, Turkey (Türkiye) Recruiting -
Sakarya University-Anesthesiology and Reanimation Department
Sakarya, Turkey (Türkiye) Not yet recruiting
Study contacts
- Study coordinator: Burçin Alaçam
- Email: burcin.ersoy90@gmail.com
- Phone: +905465903851
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.