Protecting kidneys with a tailored low-protein diet approach for advanced CKD
Official title: Protecting Kidneys Through a Low Protein Diet: A Stepwise Multiple-Choice System Approach
Run by Centre Hospitalier le Mans · NCT03979534 · Data updated 2026-11-12
This study tests a stepwise, patient-tailored low-protein diet to slow kidney decline and delay dialysis in adults with advanced chronic kidney disease.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Centre Hospitalier le Mans Academic / other |
| Locations | 2 sites (La Flèche and 1 other locations) |
| Status | Recruiting |
| Started | April 1, 2019 |
| Main results expected | April 1, 2028 |
| Study ends | April 1, 2028 |
| Registry record updated | July 1, 2026 |
| Trial ID | NCT03979534 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with advanced CKD (stage 4-5, or stage 3 with rapid progression) who can safely follow a low-protein diet and provide informed consent.
✕Probably not a fit
Patients with malnutrition, very limited life expectancy, or contraindications to dietary restriction may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This implementation study explores how to better use low-protein diets in routine care for adults with advanced CKD (stages 3b-5 or fast-progressing stage 3). It uses a multiple-choice, adaptable dietary approach designed to fit individual patient needs and preferences, with the aim of slowing kidney function decline and postponing the start of dialysis. The study emphasizes nutrition as a core factor in patient outcomes and seeks to optimize dietary management in the real-world clinical setting. Participants will follow a low-protein diet under nephrology supervision, with outcomes informed by nutritional status and disease progression. The initiative is led by Centre Hospitalier Le Mans in France and seeks to inform best practices for integrating protein-restricted diets into standard CKD care.
Why it matters
Potential benefit: If successful, patients may experience slower CKD progression and delayed need for dialysis through personalized dietary management.
How similar studies have gone: Previous evidence supports nutritional strategies and protein restriction in CKD, but this specific stepwise, customized implementation approach is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult patients followed on the unit for advanced CKD, with Kidney disease stage 4-5 or stage 3 with fast progression and without contraindications. Exclusion Criteria: * Malnutrition or short life-expectancy * Patients aged less than 18 years old * Pregnant women, * Incapacity to complete the free-consent form, * Pateints refusing participation in the study, * Patients without healthcare coverage.
Where it's running
-
Pôle Santé Sarthe et Loir
La Flèche, France Recruiting -
Centre Hospitalier Le Mans
Le Mans, France Recruiting
Study contacts
- Principal investigator: Giorgina Piccoli, MD — Centre Hospitalier le Mans
- Study coordinator: Christelle Jadeau, PD
- Email: cjadeau@ch-lemans.fr
- Phone: 0 (33) 2 43 43 43 43
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.