Calciphylaxis in people with chronic kidney disease: causes, risks, and early signs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Danish Calciphylaxis Research Initiative (DanCaRI) enrolls adults with CKD who have suspected or newly diagnosed calciphylaxis (cases), matched CKD controls who never developed calciphylaxis, and a healthy reference group. The design combines a two-year retrospective review with prospective follow-up for three years and systematic collection of clinical data and biological samples. Cases and controls are matched to identify differences in exposures, laboratory markers, and clinical course that might indicate causes or early indicators of calciphylaxis. Results are intended to support prevention strategies, earlier diagnosis, and the design of future treatment trials.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Cases

* Age ≥18 years.
* CKD.
* Suspicion of calciphylaxis or newly diagnosed calciphylaxis episode. The suspicion or diagnosis of calciphylaxis is a mutual decision of the involved medical specialties (nephrologist, dermatologist, pathologist, other).
* Ability to give informed consent.
* Ability to participate in a clinical study as assessed by the local investigator.
* Provides written informed consent.

Controls

* Age ≥18 years.
* CKD
* Ability to give informed consent.
* Ability to participate in a clinical study as assessed by the local investigator.
* Provides written informed consent.

Healthy reference group

* Age ≥18 years.
* Self-assessed as healthy, confirmed by local investigators at inclusion

Exclusion Criteria:

Cases

\- the calciphylaxis diagnosis becomes excluded

Controls - Being diagnosed with calciphylaxis

Healthy controls Up to 60 years of age: eGFR below 60 ml/min/1.72m2.

\- Over 60 years of age: eGFR below the 95% confidence interval for eGFR adjusted for age (Danish Society of Nephrology references ranges)

Where it's running

• Odense University Hospital
  Odense, Denmark Recruiting

Study contacts

• Principal investigator: Subagini Nagarajah, PhD — Odense University Hospital
• Study coordinator: Subagini Nagarajah, PhD
• Email: subagini.nagarajah3@rsyd.dk
• Phone: +45 40498337

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.