Eye-brain-kidney connections in chronic kidney disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center observational cohort will enroll adults aged 18–70 with CKD stages 1–5 at Beijing Friendship Hospital. Participants will complete neuropsychological testing (including the Montreal Cognitive Assessment), blood tests for biomarkers, and multimodal imaging—3.0T brain MRI, multiparametric kidney MRI, and retinal OCT/OCTA—at baseline and at a 3-year follow-up. The study will analyze relationships among retinal microvasculature, brain connectivity and perfusion measures, cognitive performance, and kidney function over time. Findings aim to establish an integrated eye–brain–kidney framework using noninvasive imaging and clinical data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged 18-70 years.
2. Patients clinically diagnosed with CKD stages 1-5.
3. No contraindications for MRI examination (e.g., cardiac pacemaker, claustrophobia, cochlear implant, hearing aid, coronary stents implanted before 2015) and able to complete the MRI scan.

Exclusion Criteria:

1. Patients with recent or prior cerebral hemorrhage or cerebral infarction.
2. History of epileptic seizures or psychiatric disorders.
3. Patients with claustrophobia.
4. Pregnant or lactating patients.
5. Presence of other central nervous system diseases (e.g., tumor, trauma).
6. Unstable angina, congestive heart failure (NYHA class III or IV), or acute myocardial infarction.
7. Any systemic or other diseases deemed unsuitable for clinical trial participation.

Where it's running

• Beijing Friendship Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Hao Wang
• Email: wanghao4756@163.com
• Phone: +86 18810643768

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Clinical decision support to help consider SGLT2 inhibitors after AKI in type 2 diabetes

  This pilot test checks if a CDS message given to clinicians can help decide whether to consider SGLT2 inhibitors for adults with type 2 diabetes who recently had acute kidney injury.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07868666

• Impact of TAVR on kidney function in people with aortic valve disease

  This registry tests how trans-catheter aortic valve implantation affects kidney function and the risk of kidney injury in adults with aortic stenosis.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT07626710

• Calciphylaxis in people with chronic kidney disease: causes, risks, and early signs

  This project will compare adults with chronic kidney disease who develop calciphylaxis to matched CKD patients who do not, collecting clinical data and biological samples to try to find risk factors and early signs.

  Recruiting Odense University Hospital · Odense · NCT07511283

• Oral Semaglutide for CKD and MAFLD in adults with diabetes

  This study tests whether adding oral semaglutide to standard care can slow kidney and liver disease progression in adults with CKD and MAFLD who have type 2 diabetes.

  Recruiting Institute of Liver and Biliary Sciences, India · New Delhi, National Capital Territory of Delhi · NCT07391267

• Screening for chronic kidney disease

  We will see how common chronic kidney disease is among adults followed at a tertiary care center and how many cases were previously undiagnosed.

  Recruiting Institute for Clinical and Experimental Medicine · Prague · NCT07153432

• Streamlined renal denervation with Spyral for uncontrolled high blood pressure

  This trial will test whether a shorter, simpler renal denervation procedure using the Symplicity Spyral system can lower blood pressure in adults with uncontrolled hypertension.

  Recruiting at 20 sites Medtronic Vascular · Melbourne and 20 other locations · NCT07115953

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.